RetrogeneDB ID: retro_pabe_2544

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 4:107179567..107180789(-)
• Located in intron of: ENSPPYG00000014966

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: DKFZP468F2127
• Ensembl ID: ENSPPYG00000004562
• Aliases: None
• Description: keratin, type II cytoskeletal 8 [Source:RefSeq peptide;Acc:NP_001127365]

Sequence

>retro_pabe_2544
TCCTCAAGCTTCTCCCTAGTGGGCAGCAGCAGCTTCCAAGGTTGCCTGGGCGGAGGCTGTGGTAGGGTCAGCGGCGTGGG
AGGCGTCACCACCATCACAGTCAACCAGAGCCTGCTGAGCCCCCTTAACCTGGAGGTGGACCCCAACATCCAGGCTGTGT
GCACCCAGAAGAAGCAGCAGATCAAGACCCTCAACAACAAGTTTGCCTCCTTCATAGACAAGGTATGGTTCCTGGAGCAG
CAGAACAAGATGCTGGAGACTAAGTGGAGCCTCCTGCAGCAGCAGAAGATGGCTCAGAGCAACATGGACAACATGTTCCA
GAGCTACATCAACAACCTTAGGTGGCAGCTGAAGACTCTGGGCCAGGAGAAGCTGAAGCTGGAGGCGGAGCTTGGCAACA
TGCAGGGGCTTGTGGAGGACTTCAAGAACAAGTATGAGGATGAGACCAATAAGCGTACAGAGGTGGAGAATGAATTTGTC
CTTATCAAGAGGATGTGGATGAAGGTTACATGAACAAGGTAGAGCTGGAGTCTCACCTGGAAGGGCTGACTGACGAGATC
AATTTCCTCAAGCAGCTGTATGAAGAGGATATCCGGGAGCTGCAGTCCCAGATCTCGGACACATTTGTGGTGCTGTCCAT
GGACAACAGCCGCTCCCTGGGCATGAACAGCATCATCGCCGAGGTCAAGGCGCCATACGAGGAGATCGCCAACTGCAGCC
AGGCCAAGGCTGAGAGCATGTACCAGATCAAGTATGAGGAGCTGCAGATGTTGGCTGGGAAGCACAAGGATGACCTGCAG
TGTACAAAGACTGAGATTTCTGAGATGAACTGGAACATCAGCCGGCTCCAGGCTGAGACTGAGGGCCTCAAAGGCCAGAG
GGCTTCCCTGGAGGCTGCCATCACAGATGTCGGCAGCACAGGGAGCTGGCTGTTAAGGATGCCAACGCCAAGCTGTCTAA
GCTGGAGGCCGCCCTGCAGCGGGCCAAGCAGGACATGGCGTGGCAACTACTTGAGTACCAGGAACTGATGAACGTCAAGC
TGGCCCTGGACATCGAGATAGCCACCTACAGGAAGCTGCTGGAGGGCGAGGAGAGCCAGCTGGACTCTGGGATGCAGAAT
ATGAGTATCCATACAAAGACCACCAATGGTTATGCAGGTGATCTGAGCTCGGCCTATGGGGGCCTCCCAAGCCCCAGCTT
TGGCTCTGGCGTGGGCTCCAGC

Alignment

ORF - retro_pabe_2544 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 83.17 %
• Parental protein coverage: 90.29 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  SSSSSRV-SSSFG--LGGYGG--SGMGGITAVTVNQSL-SPV-LEVDPNI-AVRTQEKEQIKTLNNKFAS
          SSS.S.V.SSSF...LGG..G..SG.GG.T..TVNQSL.SP..LEVDPNI.AV.TQ.K.QIKTLNNKFAS
Retrocopy SSSFSLVGSSSFQGCLGGGCGRVSGVGGVTTITVNQSLLSPLNLEVDPNIQAVCTQKKQQIKTLNNKFAS

Parental  FIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVED
          FIDKV.FLEQQNKMLETKWSLLQQQK.A.SNMDNMF.SYINNLR.QL.TLGQEKLKLEAELGNMQGLVED
Retrocopy FIDKVWFLEQQNKMLETKWSLLQQQKMAQSNMDNMFQSYINNLRWQLKTLGQEKLKLEAELGNMQGLVED

Parental  FKNKYEDEINKRTEMENEFVLIKK-DVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTS
          FKNKYEDE.NKRTE.ENEFVLIK..DVDE.YMNKVELES.LEGLTDEINFL.QLYEE.IRELQSQISDT.
Retrocopy FKNKYEDETNKRTEVENEFVLIKR<DVDEGYMNKVELESHLEGLTDEINFLKQLYEEDIRELQSQISDTF

Parental  VVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRN
          VVLSMDNSRSL.M.SIIAEVKA.YE.IAN.S.A.AESMYQIKYEELQ.LAGKH.DDL..TKTEISEMN.N
Retrocopy VVLSMDNSRSLGMNSIIAEVKAPYEEIANCSQAKAESMYQIKYEELQMLAGKHKDDLQCTKTEISEMNWN

Parental  ISRLQAEIEGLKGQRASLEAAIAD-AEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKL
          ISRLQAE.EGLKGQRASLEAAI.D...Q..ELA.KDANAKLS.LEAALQRAKQDMA.QL.EYQELMNVKL
Retrocopy ISRLQAETEGLKGQRASLEAAITD<CRQHRELAVKDANAKLSKLEAALQRAKQDMAWQLLEYQELMNVKL

Parental  ALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYGLGSS
          ALDIEIATYRKLLEGEES.L.SGMQNMSIHTKTT.GYAG.LSSAYGGL.SP....G.GSS
Retrocopy ALDIEIATYRKLLEGEESQLDSGMQNMSIHTKTTNGYAGDLSSAYGGLPSPSFGSGVGSS

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.39 RPM	0.55 RPM
SRP007412_cerebellum	0.85 RPM	0.12 RPM
SRP007412_heart	1.23 RPM	23.57 RPM
SRP007412_kidney	0.36 RPM	106.83 RPM
SRP007412_liver	0.15 RPM	163.17 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_2544 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_2544 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_2544 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_3069

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Parental genes homology:

Parental genes homology involve 17 parental genes, and 152 retrocopies.

Species	Parental gene accession	Retrocopies number
Canis familiaris	ENSCAFG00000007199	2 retrocopies	retro_cfam_1036, retro_cfam_1590,
Callithrix jacchus	ENSCJAG00000018147	3 retrocopies	retro_cjac_124, retro_cjac_167, retro_cjac_216,
Cavia porcellus	ENSCPOG00000002615	5 retrocopies	retro_cpor_1269, retro_cpor_1459, retro_cpor_233, retro_cpor_302, retro_cpor_516,
Dasypus novemcinctus	ENSDNOG00000007400	3 retrocopies	retro_dnov_1267, retro_dnov_1886, retro_dnov_2358,
Felis catus	ENSFCAG00000000298	2 retrocopies	retro_fcat_1142, retro_fcat_891,
Homo sapiens	ENSG00000170421	28 retrocopies	retro_hsap_1012, retro_hsap_1024, retro_hsap_1324, retro_hsap_1513, retro_hsap_1557, retro_hsap_1599, retro_hsap_169, retro_hsap_1708, retro_hsap_235, retro_hsap_2354, retro_hsap_2669, retro_hsap_2731, retro_hsap_2768, retro_hsap_2797, retro_hsap_2842, retro_hsap_3069, retro_hsap_3359, retro_hsap_3379, retro_hsap_3433, retro_hsap_371, retro_hsap_3963, retro_hsap_4203, retro_hsap_4688, retro_hsap_4691, retro_hsap_4775, retro_hsap_644, retro_hsap_844, retro_hsap_932,
Gorilla gorilla	ENSGGOG00000014673	18 retrocopies	retro_ggor_1160, retro_ggor_1787, retro_ggor_1862, retro_ggor_1897, retro_ggor_1900, retro_ggor_2320, retro_ggor_2662, retro_ggor_2913, retro_ggor_2918, retro_ggor_297, retro_ggor_2975, retro_ggor_382, retro_ggor_564, retro_ggor_66, retro_ggor_691, retro_ggor_751, retro_ggor_803, retro_ggor_809,
Macaca mulatta	ENSMMUG00000002163	22 retrocopies	retro_mmul_1069, retro_mmul_1122, retro_mmul_1178, retro_mmul_1349, retro_mmul_1351, retro_mmul_1412, retro_mmul_1697, retro_mmul_1753, retro_mmul_1810, retro_mmul_1855, retro_mmul_1866, retro_mmul_2097, retro_mmul_2137, retro_mmul_2357, retro_mmul_2431, retro_mmul_2546, retro_mmul_289, retro_mmul_488, retro_mmul_58, retro_mmul_766, retro_mmul_816, retro_mmul_886,
Mustela putorius furo	ENSMPUG00000006441	7 retrocopies	retro_mputfur_1101, retro_mputfur_1208, retro_mputfur_1271, retro_mputfur_1557, retro_mputfur_1587, retro_mputfur_556, retro_mputfur_895,
Mus musculus	ENSMUSG00000049382	1 retrocopy	retro_mmus_2905,
Nomascus leucogenys	ENSNLEG00000017733	8 retrocopies	retro_nleu_1913, retro_nleu_225, retro_nleu_2285, retro_nleu_2421, retro_nleu_2485, retro_nleu_2727, retro_nleu_2787, retro_nleu_672,
Oryctolagus cuniculus	ENSOCUG00000006945	1 retrocopy	retro_ocun_313,
Otolemur garnettii	ENSOGAG00000011740	16 retrocopies	retro_ogar_1076, retro_ogar_1162, retro_ogar_1256, retro_ogar_1572, retro_ogar_1874, retro_ogar_1898, retro_ogar_1952, retro_ogar_2004, retro_ogar_2149, retro_ogar_2177, retro_ogar_2261, retro_ogar_2500, retro_ogar_3198, retro_ogar_3318, retro_ogar_339, retro_ogar_664,
Pongo abelii	ENSPPYG00000004548	1 retrocopy	retro_pabe_1103,
Pongo abelii	ENSPPYG00000004562	31 retrocopies	retro_pabe_1102, retro_pabe_1261, retro_pabe_1289, retro_pabe_1460, retro_pabe_1743, retro_pabe_2063, retro_pabe_2077, retro_pabe_2129, retro_pabe_2142, retro_pabe_2214, retro_pabe_2270, retro_pabe_2352, retro_pabe_2544 , retro_pabe_2741, retro_pabe_2763, retro_pabe_2787, retro_pabe_2842, retro_pabe_2926, retro_pabe_2943, retro_pabe_3138, retro_pabe_332, retro_pabe_3439, retro_pabe_3644, retro_pabe_3716, retro_pabe_417, retro_pabe_460, retro_pabe_569, retro_pabe_605, retro_pabe_701, retro_pabe_803, retro_pabe_851,
Pteropus vampyrus	ENSPVAG00000009360	3 retrocopies	retro_pvam_1299, retro_pvam_1396, retro_pvam_45,
Rattus norvegicus	ENSRNOG00000009779	1 retrocopy	retro_rnor_807,