RetrogeneDB ID: retro_ggor_1726

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 2b:58588633..58589569(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSGGOG00000026007
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: EIF2S2
• Ensembl ID: ENSGGOG00000015546
• Aliases: None
• Description: None

Sequence

>retro_ggor_1726
CCTTTTATGTTGGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCAGAGCC
AACTGAGGACAAAGATTTGGAAGCTGATAAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACT
TCTTTAATCAAAAGAAAAAGAAGAAAAAAACTAAACAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTT
AAGATTGAAAGTGATGTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGACAATAAAAAGAAGAAAAA
GAAGAATGTTAAGTTCCCAGATGAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATG
ACGGTATCTCATTCAGTAATCAGACAGGCCCTGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAAT
CGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCACA
AGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGTAAACTATTACATCGTCAGCCCAAAC
ATCTCCTTGCATTTTTATTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTTGTAATCAAAGGAAGA
TTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCACCGGA
CACAATCCTGCAGAAGGACACACGACTTTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCATTATCA
AAACCGGCTTCCAGGCTGTCATGGGCAAGCGAGCACAGCTCCGTGCCAAAGCTAAC

Alignment

ORF - retro_ggor_1726 Open Reading Frame is conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 93.59 %
• Parental protein coverage: 96.3 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  PFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKKIFDI
          PFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEAD.EDTRKKDASDDLDDLNFFN........K.IFDI
Retrocopy PFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADKEDTRKKDASDDLDDLNFFNXXXXXXXXKQIFDI

Parental  DEAEEGVKDLKIESDVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSN
          DEAEEGVKDLKIESDVQEPTEPEDDLDIML.N.......VKFPDEDEILEKDEALEDEDNKKDDGISFSN
Retrocopy DEAEEGVKDLKIESDVQEPTEPEDDLDIMLDNXXXXXXXVKFPDEDEILEKDEALEDEDNKKDDGISFSN

Parental  QTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHR
          QTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHR
Retrocopy QTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHR

Parental  QPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQ
          QPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQ
Retrocopy QPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQ

Parental  CETCHSRCSVASIKTGFQAVTGKRAQLRAKAN
          CETCHSRCSVA.IKTGFQAV.GKRAQLRAKAN
Retrocopy CETCHSRCSVAIIKTGFQAVMGKRAQLRAKAN

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.34 RPM	21.34 RPM
SRP007412_cerebellum	0.43 RPM	20.37 RPM
SRP007412_heart	0.09 RPM	8.69 RPM
SRP007412_kidney	0.53 RPM	41.34 RPM
SRP007412_liver	0.61 RPM	25.32 RPM
SRP007412_testis	1.45 RPM	52.63 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_1726 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_1726 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_2176

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Parental genes homology:

Parental genes homology involve 13 parental genes, and 27 retrocopies.

Species	Parental gene accession	Retrocopies number
Callithrix jacchus	ENSCJAG00000018334	2 retrocopies	retro_cjac_4196, retro_cjac_697,
Cavia porcellus	ENSCPOG00000015439	1 retrocopy	retro_cpor_1143,
Echinops telfairi	ENSETEG00000001922	1 retrocopy	retro_etel_1101,
Homo sapiens	ENSG00000125977	3 retrocopies	retro_hsap_2176, retro_hsap_2260, retro_hsap_713,
Gorilla gorilla	ENSGGOG00000015546	5 retrocopies	retro_ggor_1683, retro_ggor_1726 , retro_ggor_2007, retro_ggor_280, retro_ggor_604,
Microcebus murinus	ENSMICG00000006944	1 retrocopy	retro_mmur_1583,
Macaca mulatta	ENSMMUG00000018095	1 retrocopy	retro_mmul_1483,
Monodelphis domestica	ENSMODG00000002805	5 retrocopies	retro_mdom_1981, retro_mdom_365, retro_mdom_368, retro_mdom_370, retro_mdom_837,
Nomascus leucogenys	ENSNLEG00000010034	2 retrocopies	retro_nleu_2242, retro_nleu_466,
Otolemur garnettii	ENSOGAG00000001417	1 retrocopy	retro_ogar_196,
Pongo abelii	ENSPPYG00000010933	2 retrocopies	retro_pabe_1955, retro_pabe_2421,
Pan troglodytes	ENSPTRG00000013412	2 retrocopies	retro_ptro_1600, retro_ptro_508,
Rattus norvegicus	ENSRNOG00000017447	1 retrocopy	retro_rnor_2395,