RetrogeneDB ID: retro_ptro_2145

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: 5:45863122..45863863(+)
• Located in intron of: ENSPTRG00000016949

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: TAF9B
• Ensembl ID: ENSPTRG00000022053
• Aliases: None
• Description: TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa [Source:HGNC Symbol;Acc:17306]

Sequence

>retro_ptro_2145
ATGGAGTCTGGCAAGATGGCTTCTCCCAAGAGCATGCCGAAAGATGCACAGATGATGGCACAAATCCTGAAGGATATGGG
GATTACAGAATATGAGCCAAGAGTTATAAATCAGATGTTGGAGTTTGCCTTCCGATATGTGACCACAATTCTAGATGATG
CAAAAATTTATTCAAGCCATGCTAAGAAAGCTACTGTTGATGCAGATGATGTGCGATTGGCAATCCAGTGCCGCGCTGAT
CAGTCTTTTACCTCTCCTCCCCCAAGAGATTTTTTATTAGATATTGCAAGGCAAAGAAATCAAACCCCTTTGCCATTGAT
CAAGCCATATTCAGGTCCTAGGTTGCCACCTGATAGATACTGCTTAACAGCTCCAAACTATAGGCTGAAATCTTTACAGA
AAAAGGCATCAACTTCTGCGGGAAGAATAACAGTCCCGCGGTTAAGTGTTGGTTCAGTTACTAGCAGACCAAGTACTCCC
ACACTAGGCACACCAACCCCACAGACCATGTCTGTTTCAACTAAAGTAGGGACTCCCATGTCCCTCACAGGTCAAAGGTT
TACAGTACAGATGCCTACTTCTCAGTCTCCAGCTGTAAAAGCTTCAATTCCTGCAACCTCAGCAGTTCAGAATGTTCTGA
TTAATCCATCATTAATCGGGTCCAAAAACATTCTTATTACCACTAATATGGTGTCATCACAAAATACTGCCAATGAATCA
TCAAATGCACTGAAAAGAAAA

Alignment

ORF - retro_ptro_2145 Open Reading Frame is conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 81.78 %
• Parental protein coverage: 96.02 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  MESGKMAPPKNAPRDALVMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSHAKKPNVDADD
          MESGKMA.PK..P.DA..MAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSHAKK..VDADD
Retrocopy MESGKMASPKSMPKDAQMMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSHAKKATVDADD

Parental  VRLAIQCRADQSFTSPPPRDFLLDIARQKNQTPLPLIKPYAGPRLPPDRYCLTAPNYRLKSLIKK-GPNQ
          VRLAIQCRADQSFTSPPPRDFLLDIARQ.NQTPLPLIKPY.GPRLPPDRYCLTAPNYRLKSL.KK.....
Retrocopy VRLAIQCRADQSFTSPPPRDFLLDIARQRNQTPLPLIKPYSGPRLPPDRYCLTAPNYRLKSLQKKASTSA

Parental  GRL-VPRLSVGAVSSKPTTPTIA--TPQTVSVPNKVATPMSVTSQRFTVQIPPSQSTPVK-PVPATTAVQ
          GR..VPRLSVG.V.S.P.TPT....TPQT.SV..KV.TPMS.T.QRFTVQ.P.SQS..VK...PAT.AVQ
Retrocopy GRITVPRLSVGSVTSRPSTPTLGTPTPQTMSVSTKVGTPMSLTGQRFTVQMPTSQSPAVKASIPATSAVQ

Parental  NVLINPSMIGPKNILITTNMVSSQNTANE-ANPLKRK
          NVLINPS.IG.KNILITTNMVSSQNTANE..N.LKRK
Retrocopy NVLINPSLIGSKNILITTNMVSSQNTANESSNALKRK

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	27.99 RPM	23.33 RPM
SRP007412_cerebellum	20.33 RPM	17.53 RPM
SRP007412_heart	17.28 RPM	17.55 RPM
SRP007412_kidney	19.14 RPM	21.55 RPM
SRP007412_liver	20.07 RPM	5.11 RPM
SRP007412_testis	268.73 RPM	11.70 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_2145 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_2145 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_2145 has 6 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Pongo abelii	retro_pabe_2748
Mus musculus	retro_mmus_161
Rattus norvegicus	retro_rnor_1492
Oryctolagus cuniculus	retro_ocun_490
Bos taurus	retro_btau_196
Canis familiaris	retro_cfam_192

---

Parental genes homology:

Parental genes homology involve 28 parental genes, and 46 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000017613	1 retrocopy	retro_amel_449,
Bos taurus	ENSBTAG00000000895	1 retrocopy	retro_btau_196,
Canis familiaris	ENSCAFG00000017278	1 retrocopy	retro_cfam_192,
Callithrix jacchus	ENSCJAG00000019520	1 retrocopy	retro_cjac_246,
Cavia porcellus	ENSCPOG00000002098	2 retrocopies	retro_cpor_906, retro_cpor_967,
Equus caballus	ENSECAG00000010189	1 retrocopy	retro_ecab_303,
Erinaceus europaeus	ENSEEUG00000010916	1 retrocopy	retro_eeur_18,
Felis catus	ENSFCAG00000025493	2 retrocopies	retro_fcat_1036, retro_fcat_260,
Homo sapiens	ENSG00000187325	1 retrocopy	retro_hsap_2619,
Gorilla gorilla	ENSGGOG00000002470	2 retrocopies	retro_ggor_1833, retro_ggor_45,
Macropus eugenii	ENSMEUG00000009697	1 retrocopy	retro_meug_140,
Myotis lucifugus	ENSMLUG00000014581	1 retrocopy	retro_mluc_519,
Macaca mulatta	ENSMMUG00000012875	1 retrocopy	retro_mmul_1480,
Monodelphis domestica	ENSMODG00000004077	1 retrocopy	retro_mdom_850,
Mustela putorius furo	ENSMPUG00000000084	1 retrocopy	retro_mputfur_63,
Mus musculus	ENSMUSG00000047242	1 retrocopy	retro_mmus_161,
Nomascus leucogenys	ENSNLEG00000001378	5 retrocopies	retro_nleu_1677, retro_nleu_2566, retro_nleu_637, retro_nleu_920, retro_nleu_932,
Oryctolagus cuniculus	ENSOCUG00000014717	1 retrocopy	retro_ocun_490,
Otolemur garnettii	ENSOGAG00000011107	3 retrocopies	retro_ogar_1128, retro_ogar_3100, retro_ogar_679,
Pongo abelii	ENSPPYG00000020497	4 retrocopies	retro_pabe_1634, retro_pabe_2341, retro_pabe_2748, retro_pabe_941,
Pan troglodytes	ENSPTRG00000022053	4 retrocopies	retro_ptro_1329, retro_ptro_1765, retro_ptro_2145 , retro_ptro_772,
Pteropus vampyrus	ENSPVAG00000017408	1 retrocopy	retro_pvam_6,
Rattus norvegicus	ENSRNOG00000002453	1 retrocopy	retro_rnor_1492,
Sus scrofa	ENSSSCG00000026714	2 retrocopies	retro_sscr_1080, retro_sscr_525,
Ictidomys tridecemlineatus	ENSSTOG00000001982	3 retrocopies	retro_itri_1640, retro_itri_411, retro_itri_763,
Tarsius syrichta	ENSTSYG00000007968	1 retrocopy	retro_tsyr_3,
Tursiops truncatus	ENSTTRG00000015964	1 retrocopy	retro_ttru_572,
Vicugna pacos	ENSVPAG00000001210	1 retrocopy	retro_vpac_16,