RetrogeneDB ID: retro_ggor_2510

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 7:29515152..29515736(+)
• Located in intron of: ENSGGOG00000012719

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: ENSG00000111704
• Ensembl ID: ENSGGOG00000028196
• Aliases: None
• Description: None

Sequence

>retro_ggor_2510
ATGAGTGTGGATCTGGCTTGTCTGCAAAGCTTGCCTTGCTTCGAAGCATGCGACTGTAAAGAATCTTCACCTATGGCTGT
GATTTGTGGGCCTGAAGAAAACCATCCATCCTTGCAAATGTCTTCTGCTGAGATGCCTCACACGGAGACTGTCTCTCCTC
TTCTTCCTCCGTGGATCTGCTTATTCAGGACAGCCCTGATTCTTCCACCAGTCCCAAAGGCAAACAACCCATTGCTGCAG
AGAATAGTGCCCCAAAAAAGGGAGGCAAGGTCCCAGTCAAGAAACAGAAGACCAGAACTGTGTTTTCTTCCACCCAGCTG
TGTGTACTCAATGATAGATTTCAGAGACAGAAATACCTCAGCCTCCAGCAGATGCAAGAACTCTCCAATATCTGGAACCT
CAGCTACAAGCAGGTGAAGACCTGGTTCTAGAACCAGAGAATGAAATCTAAGAGGTGGCAGAAAAACAACTGGCCGAAGA
ATAGCAATGGTGTGACTCGGAAGGCCTCAGCACCTACCTACCCCAGCCACTACTCTTCCTGCCACCAGGGATGACTGATG
AACCTGACTGGGAACCTTCCGATG

Alignment

ORF - retro_ggor_2510 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 87.76 %
• Parental protein coverage: 63.93 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  MSVDPACPQSLPCFEASDCKESSPMPVICGPEENYPSLQMSSAEIPHTETVSPL-PSSMDLPIQDSPDSS
          MSVD.AC.QSLPCFEA.DCKESSPM.VICGPEEN.PSLQMSSAE.PHTETVSPL..SS.DL.IQDSPDSS
Retrocopy MSVDLACLQSLPCFEACDCKESSPMAVICGPEENHPSLQMSSAEMPHTETVSPL<SSSVDLLIQDSPDSS

Parental  TSPKGKQPTSAEKSATKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQV
          TSPKGKQP..AE.SA.KK..KVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNI.NLSYKQV
Retrocopy TSPKGKQPIAAENSAPKKGGKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNIWNLSYKQV

Parental  KTWFQNQRMKSKRWQKNNWPKNSNGVTQKASAPTYPSLYSSYHQGCLVNPTGNLPM
          KTWF.NQRMKSKRWQKNNWPKNSNGVT.KASAPTYPS.YSS.HQG.L.N.TGNLPM
Retrocopy KTWF*NQRMKSKRWQKNNWPKNSNGVTRKASAPTYPSHYSSCHQG*LMNLTGNLPM

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	0.48 RPM
SRP007412_cerebellum	0.55 RPM	0.08 RPM
SRP007412_heart	0.00 RPM	0.09 RPM
SRP007412_kidney	0.04 RPM	0.45 RPM
SRP007412_liver	0.11 RPM	0.13 RPM
SRP007412_testis	0.00 RPM	0.41 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_2510 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_2510 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_3713
Pan troglodytes	retro_ptro_2514
Pongo abelii	retro_pabe_3142

---

Parental genes homology:

Parental genes homology involve 22 parental genes, and 59 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000017064	1 retrocopy	retro_amel_354,
Canis familiaris	ENSCAFG00000013914	1 retrocopy	retro_cfam_724,
Choloepus hoffmanni	ENSCHOG00000000972	4 retrocopies	retro_chof_1267, retro_chof_264, retro_chof_794, retro_chof_987,
Cavia porcellus	ENSCPOG00000002621	1 retrocopy	retro_cpor_1132,
Echinops telfairi	ENSETEG00000004648	8 retrocopies	retro_etel_1155, retro_etel_1334, retro_etel_134, retro_etel_1434, retro_etel_1935, retro_etel_630, retro_etel_818, retro_etel_963,
Felis catus	ENSFCAG00000001621	1 retrocopy	retro_fcat_932,
Homo sapiens	ENSG00000111704	5 retrocopies	retro_hsap_1455, retro_hsap_1549, retro_hsap_3713, retro_hsap_4814, retro_hsap_722,
Gorilla gorilla	ENSGGOG00000028196	4 retrocopies	retro_ggor_1812, retro_ggor_2510 , retro_ggor_3000, retro_ggor_608,
Macropus eugenii	ENSMEUG00000009949	2 retrocopies	retro_meug_266, retro_meug_940,
Microcebus murinus	ENSMICG00000002228	1 retrocopy	retro_mmur_575,
Myotis lucifugus	ENSMLUG00000029325	2 retrocopies	retro_mluc_1562, retro_mluc_2054,
Myotis lucifugus	ENSMLUG00000030580	1 retrocopy	retro_mluc_169,
Macaca mulatta	ENSMMUG00000032158	4 retrocopies	retro_mmul_1901, retro_mmul_2466, retro_mmul_964, retro_mmul_979,
Monodelphis domestica	ENSMODG00000017979	2 retrocopies	retro_mdom_1293, retro_mdom_1938,
Mustela putorius furo	ENSMPUG00000016731	5 retrocopies	retro_mputfur_1140, retro_mputfur_1553, retro_mputfur_261, retro_mputfur_553, retro_mputfur_691,
Nomascus leucogenys	ENSNLEG00000005359	3 retrocopies	retro_nleu_1086, retro_nleu_2189, retro_nleu_2340,
Oryctolagus cuniculus	ENSOCUG00000013783	1 retrocopy	retro_ocun_971,
Otolemur garnettii	ENSOGAG00000026339	1 retrocopy	retro_ogar_568,
Procavia capensis	ENSPCAG00000015460	2 retrocopies	retro_pcap_143, retro_pcap_429,
Pongo abelii	ENSPPYG00000004233	5 retrocopies	retro_pabe_2157, retro_pabe_3142, retro_pabe_3440, retro_pabe_3742, retro_pabe_623,
Pan troglodytes	ENSPTRG00000029807	4 retrocopies	retro_ptro_1746, retro_ptro_2514, retro_ptro_3203, retro_ptro_990,
Pteropus vampyrus	ENSPVAG00000006989	1 retrocopy	retro_pvam_1251,