RetrogeneDB ID:

retro_hsap_1648

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:16:69067556..69068424(+)
Located in intron of:ENSG00000103047
Retrocopy
information
Ensembl ID:ENSG00000244378
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:RPS2
Ensembl ID:ENSG00000140988
Aliases:RPS2, LLREP3, S2
Description:ribosomal protein S2 [Source:HGNC Symbol;Acc:10404]


Retrocopy-Parental alignment summary:






>retro_hsap_1648
CTGGAGGATAACGCCAATGTGGCGGGAGGTCCTGGAGGCCCTGGGGACCCTAAATGGAAAACTGCCATGGCTTCCTCAGA
GGCTTTGGTAGCAGCATGCAGGACTGGGCTCGCAGCCATGGTCAAGGCTAGAGCTGAGGCTGTGGAACTCACAGAGACAT
GACTGAGGACAAGGAGTGGATACCCATCACCAAGCTGGTCCCTCTGGTCAAGGATATGAAGATCAAGTCCCTGGAGACCT
ATCTCTTCTCCCTGCCCATCGAGGAGTGTGATATCATTAGCTTTTTTCAAGGGGCATCTCTCATGGGTGAGGTTTTAAAG
ATTATGCTTGTGTAGAAACAGACCCACACTGGCCACCGCACCAGATTCAAGGCATTTGTTACTGTTAGGGACTATGATGG
CCACATCAGTTTAAGTGTTAAGTGCTCCAAGGAGGTTACTACTGCCATCCAAGGGACCATCACCCTGGCCAAGCTTTCCA
TTGTCCCTATGCGGAGAGGTTACTGGGGGAACAAGATCGGCAAGTCCTACACCACCCCCTGTATGGTTACAGGCTGCTGT
AGCTCTGGGCTAGTACACCTTATCCCTGCCCCCAGGAACAATGGCATCATCTCGACTCCTGTGCCCAAGATGCTGCTGCT
GATGGCCGGTATTGACAACTGCTACACCTCAGCCAGGGGCTGCACTGCCACCCTGGACAACTTCACCAAGGCCACCTTCA
ATGCCATCTCCAGGACCTATAGCTGCCTGACCCCCAGCCTCTGGAAAGAGACTATTCACCAAGCCTCCCTGTGGAATGCA
CTGACCATCACATCAAGACCCACACCAGAGCCTCCATGCAGAGGACCCAGGCTCCAGCTGTGGTTACA

ORF - retro_hsap_1648 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 66.67 %
Parental protein coverage: 99.66 %
Number of stop codons detected: 4
Number of frameshifts detected 2


Retrocopy - Parental Gene Alignment:

ParentalMADDAGAAGGPGGPG-GPGMGNRGGFRGGFGSGIRGRGRGRGRGRGRGRGARGGKAEDKEWMPVTKLGRL
..D.A..AGGPGGPG.GP.M.N..GF..GFGS......R..G.G...G.G......EDKEW.P.TKL..L
RetrocopyLEDNANVAGGPGGPG<GP*MENCHGFLRGFGSSMQDWARSHGQG*S*GCGTHRDMTEDKEWIPITKLVPL
ParentalVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGL
VKDMKIKSLE..YLFSLPI.E..II.FF.GASL..EVLKIM.V.KQT..G.RTRFKAFV...DY.GH..L
RetrocopyVKDMKIKSLET-YLFSLPIEECDIISFFQGASLMGEVLKIMLV*KQTHTGHRTRFKAFVTVRDYDGHISL
ParentalGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPV
.VKCSKEV.TAI.G.I.LAKLSIVP.RRGYWGNKIGK..T.PC.VTG.C.S.LV.LIPAPR..GI.S.PV
RetrocopySVKCSKEVTTAIQGTITLAKLSIVPMRRGYWGNKIGKSYTTPCMVTGCCSSGLVHLIPAPRNNGIISTPV
ParentalPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFT-DHLVKTHT
PK.LL.MAGID.CYTSARGCTATL.NF.KATF.AIS.TYS.LTP.LWKET....S.....T..H..KTHT
RetrocopyPKMLLLMAGIDNCYTSARGCTATLDNFTKATFNAISRTYSCLTPSLWKETIHQASLWNALT<HHI-KTHT
ParentalRVSVQRTQAPAVAT
R.S.QRTQAPAV.T
RetrocopyRASMQRTQAPAVVT

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 496 .47 RPM
bodymap2_adrenal 0 .02 RPM 505 .10 RPM
bodymap2_brain 0 .09 RPM 53 .79 RPM
bodymap2_breast 0 .08 RPM 261 .89 RPM
bodymap2_colon 0 .00 RPM 444 .16 RPM
bodymap2_heart 0 .00 RPM 116 .21 RPM
bodymap2_kidney 0 .00 RPM 179 .65 RPM
bodymap2_liver 0 .00 RPM 249 .89 RPM
bodymap2_lung 0 .00 RPM 464 .79 RPM
bodymap2_lymph_node 0 .00 RPM 651 .42 RPM
bodymap2_ovary 0 .02 RPM 445 .62 RPM
bodymap2_prostate 0 .00 RPM 603 .00 RPM
bodymap2_skeletal_muscle 0 .00 RPM 731 .68 RPM
bodymap2_testis 0 .32 RPM 238 .89 RPM
bodymap2_thyroid 0 .04 RPM 257 .52 RPM
bodymap2_white_blood_cells 0 .00 RPM 782 .33 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_1648 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_1648 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_1648 retrocopy 5' end.

Lab - click to see more details

retro_hsap_1648 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_1648 has 0 orthologous retrocopies within eutheria group .

Parental genes homology:
Parental genes homology involve 6 parental genes, and 79 retrocopies.

Species Parental gene accession Retrocopies number
Anolis carolinensis ENSACAG000000025491 retrocopy
retro_acar_57,
Felis catus ENSFCAG000000291916 retrocopies
retro_fcat_1245, retro_fcat_1328, retro_fcat_1606, retro_fcat_1610, retro_fcat_1737, retro_fcat_517,
Homo sapiens ENSG00000140988 47 retrocopies
retro_hsap_1060, retro_hsap_136, retro_hsap_140, retro_hsap_141, retro_hsap_1443, retro_hsap_1444, retro_hsap_1457, retro_hsap_1463, retro_hsap_148, retro_hsap_1648 , retro_hsap_1688, retro_hsap_1722, retro_hsap_1812, retro_hsap_1830, retro_hsap_1831, retro_hsap_1838, retro_hsap_1845, retro_hsap_1897, retro_hsap_1953, retro_hsap_1965, retro_hsap_1971, retro_hsap_2124, retro_hsap_2198, retro_hsap_2424, retro_hsap_244, retro_hsap_2483, retro_hsap_2486, retro_hsap_250, retro_hsap_282, retro_hsap_2871, retro_hsap_3035, retro_hsap_3097, retro_hsap_3106, retro_hsap_3182, retro_hsap_3211, retro_hsap_3369, retro_hsap_3464, retro_hsap_3584, retro_hsap_3779, retro_hsap_385, retro_hsap_4094, retro_hsap_4290, retro_hsap_435, retro_hsap_4811, retro_hsap_754, retro_hsap_761, retro_hsap_970,
Monodelphis domestica ENSMODG000000160771 retrocopy
retro_mdom_536,
Otolemur garnettii ENSOGAG0000001009819 retrocopies
retro_ogar_1051, retro_ogar_1120, retro_ogar_1205, retro_ogar_1557, retro_ogar_1821, retro_ogar_1835, retro_ogar_1837, retro_ogar_1851, retro_ogar_2101, retro_ogar_2164, retro_ogar_2313, retro_ogar_2648, retro_ogar_2817, retro_ogar_2842, retro_ogar_2965, retro_ogar_3109, retro_ogar_3177, retro_ogar_3180, retro_ogar_794,
Sarcophilus harrisii ENSSHAG000000152135 retrocopies
retro_shar_186, retro_shar_288, retro_shar_456, retro_shar_525, retro_shar_783,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.1 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .02 RPM
CEU_NA11843 0 .03 RPM
CEU_NA11930 0 .03 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .00 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .04 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .03 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .03 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .03 RPM
GBR_HG00111 0 .02 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .03 RPM
GBR_HG00143 0 .03 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .07 RPM
TSI_NA20538 0 .05 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .06 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .10 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .02 RPM
YRI_NA19213 0 .02 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .02 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).



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