RetrogeneDB ID: retro_ptro_547

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: 11:61554466..61554965(+)
• Located in intron of: ENSPTRG00000003807

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: IMMP1L
• Ensembl ID: ENSPTRG00000003472
• Aliases: None
• Description: IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) [Source:HGNC Symbol;Acc:26317]

Sequence

>retro_ptro_547
ATGCTTCGTGGTGCTCTGGGGAAACCTTCTGACTTGTTGGCTATGCTATTCAGTATGGCTGTATAGCTCACTGTGCTTTT
GAATACGTTGGTGGTGTTGTCATGTGTTCTGGACCATCAATGGAGCCTACAATTCAAAATTCAGATACTGTCTTTGCAGA
AAATCTTAGTCGACATTTTTATAGTATCCAAAGAGGTGACATTGTGATTGCAAAAAGCCCAAGTGATCCAACATCAAATC
TTTGTAAAAGAGTAACTGGTTTGGAAGGAGACAAAATCCTCACCACTAGTCCATCAGATTTCTTTAAAAGCTACAGTTAT
GTCCCAGTGGGTCACGTTTGGTTAGAAGGTGATAAATCTACAGAATTCTACAGATTCCAGTTACTATGGACCTATTCCAT
ATGAACTAATAAGAGGACGAATCTTCTTTTAAGATTCGGCCTCTGAGTGATTTTGGATTTTTATGTGCCAGCCTTAATGG
CCACAGATTTTCTGATGAT

Alignment

ORF - retro_ptro_547 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 88.76 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 1
• Number of frameshifts detected: 3

Retrocopy - Parental Gene Alignment:

Parental  MLRGVLGK-TFRLVGYTIQYGCIAHCAFEYVGGVVMCSGPSMEPTIQNSDIVFAENLSRHFYGIQRGDIV
          MLRG.LGK.TF.LVGY.IQYGCIAHCAFEYVGGVVMCSGPSMEPTIQNSD.VFAENLSRHFY.IQRGDIV
Retrocopy MLRGALGK<TF*LVGYAIQYGCIAHCAFEYVGGVVMCSGPSMEPTIQNSDTVFAENLSRHFYSIQRGDIV

Parental  IAKSPSDPKSNICKRVIGLEGDKILTTSPSDFFKSHSYVPMGHVWLEGD-NLQNSTDSRCYGPIPYGLIR
          IAKSPSDP.SN.CKRV.GLEGDKILTTSPSDFFKS.SYVP.GHVWLEGD.NLQNSTDS..YGPIPY.LIR
Retrocopy IAKSPSDPTSNLCKRVTGLEGDKILTTSPSDFFKSYSYVPVGHVWLEGD>NLQNSTDSSYYGPIPYELIR

Parental  GRIF-FKIWPLSDFGFLRASPNGHRFSDD
          GRIF.FKI.PLSDFGFL.AS.NGHRFSDD
Retrocopy GRIF>FKIRPLSDFGFLCASLNGHRFSDD

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.04 RPM	2.70 RPM
SRP007412_cerebellum	0.07 RPM	2.01 RPM
SRP007412_heart	0.00 RPM	2.13 RPM
SRP007412_kidney	0.03 RPM	3.56 RPM
SRP007412_liver	0.03 RPM	1.11 RPM
SRP007412_testis	1.16 RPM	6.22 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_547 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_547 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_547 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Gorilla gorilla	retro_ggor_651

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Parental genes homology:

Parental genes homology involve 27 parental genes, and 48 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000006876	1 retrocopy	retro_amel_623,
Bos taurus	ENSBTAG00000000475	1 retrocopy	retro_btau_528,
Canis familiaris	ENSCAFG00000007514	2 retrocopies	retro_cfam_1757, retro_cfam_548,
Choloepus hoffmanni	ENSCHOG00000010106	4 retrocopies	retro_chof_1157, retro_chof_1665, retro_chof_2427, retro_chof_358,
Callithrix jacchus	ENSCJAG00000006042	1 retrocopy	retro_cjac_1240,
Dipodomys ordii	ENSDORG00000000250	4 retrocopies	retro_dord_144, retro_dord_205, retro_dord_243, retro_dord_726,
Equus caballus	ENSECAG00000020512	3 retrocopies	retro_ecab_1019, retro_ecab_159, retro_ecab_920,
Echinops telfairi	ENSETEG00000003057	1 retrocopy	retro_etel_1971,
Homo sapiens	ENSG00000148950	1 retrocopy	retro_hsap_786,
Gorilla gorilla	ENSGGOG00000014897	1 retrocopy	retro_ggor_651,
Myotis lucifugus	ENSMLUG00000006504	2 retrocopies	retro_mluc_2105, retro_mluc_385,
Macaca mulatta	ENSMMUG00000016806	1 retrocopy	retro_mmul_1092,
Mus musculus	ENSMUSG00000042670	2 retrocopies	retro_mmus_2571, retro_mmus_591,
Nomascus leucogenys	ENSNLEG00000017882	1 retrocopy	retro_nleu_2484,
Oryctolagus cuniculus	ENSOCUG00000029612	1 retrocopy	retro_ocun_388,
Otolemur garnettii	ENSOGAG00000007853	3 retrocopies	retro_ogar_1202, retro_ogar_2006, retro_ogar_2643,
Pongo abelii	ENSPPYG00000003389	1 retrocopy	retro_pabe_747,
Pan troglodytes	ENSPTRG00000003472	1 retrocopy	retro_ptro_547 ,
Pteropus vampyrus	ENSPVAG00000015535	1 retrocopy	retro_pvam_932,
Rattus norvegicus	ENSRNOG00000004829	1 retrocopy	retro_rnor_2450,
Sarcophilus harrisii	ENSSHAG00000015407	2 retrocopies	retro_shar_396, retro_shar_491,
Sus scrofa	ENSSSCG00000013322	1 retrocopy	retro_sscr_1178,
Ictidomys tridecemlineatus	ENSSTOG00000003179	2 retrocopies	retro_itri_489, retro_itri_623,
Tupaia belangeri	ENSTBEG00000002126	6 retrocopies	retro_tbel_1510, retro_tbel_2503, retro_tbel_315, retro_tbel_3504, retro_tbel_4049, retro_tbel_878,
Tarsius syrichta	ENSTSYG00000009257	1 retrocopy	retro_tsyr_2139,
Tursiops truncatus	ENSTTRG00000002395	2 retrocopies	retro_ttru_1862, retro_ttru_966,
Vicugna pacos	ENSVPAG00000001940	1 retrocopy	retro_vpac_126,