RetrogeneDB ID: retro_pabe_509

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 10:29800789..29801096(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: TPRKB
• Ensembl ID: ENSPPYG00000012292
• Aliases: None
• Description: TP53RK binding protein [Source:HGNC Symbol;Acc:24259]

Sequence

>retro_pabe_509
GGAGAAATGAAGACAAGAGCTCTATCTAGTGAAATTATTTTCAACCTTTCCCCAAATAACAATATTTCAGAGGCATTGAA
AAAATGTGGTATCTCAGCAAATGACACTTAAATTCCAATTGTTTATACTAACGAGGGAGAAAAACAAATAAATCAAGGAT
ATCTAATATCTCAAATAGAAGGTTAGCAGGTTTCTCTGAAAAATCTTCCTGAAATAATAAATATTACAAAAGTCAAAAAG
AAATATACACTCCCTCCACAAGAAGAAAGTATTGGGAACATTATTGGATGGTATTTGTAGAATGTCA

Alignment

ORF - retro_pabe_509 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 68.27 %
• Parental protein coverage: 85.83 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  GDLRRKAMEGTIDGSLINPTVISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLP
          G.....A....I...L.....ISEALKK.GISANDT.I.IVY..EGEKQINQ.YLISQ.EG.QVSLKNLP
Retrocopy GEMKTRALSSEIIFNLSPNNNISEALKKCGISANDT*IPIVYTNEGEKQINQGYLISQIEG*QVSLKNLP

Parental  EITNITEVKKIYKLSSQEESI-GTLLDGIICRMS
          EI.NIT.VKK.Y.L..QEESI.GTLLDG.ICRMS
Retrocopy EIINITKVKKKYTLPPQEESI>GTLLDG-ICRMS

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.83 RPM	3.48 RPM
SRP007412_cerebellum	0.61 RPM	4.01 RPM
SRP007412_heart	0.72 RPM	4.18 RPM
SRP007412_kidney	1.09 RPM	5.34 RPM
SRP007412_liver	0.61 RPM	3.06 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_509 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_509 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_509 has 0 orthologous retrocopies within eutheria group .

---

Parental genes homology:

Parental genes homology involve 14 parental genes, and 25 retrocopies.

Species	Parental gene accession	Retrocopies number
Choloepus hoffmanni	ENSCHOG00000012021	1 retrocopy	retro_chof_35,
Callithrix jacchus	ENSCJAG00000004162	3 retrocopies	retro_cjac_1999, retro_cjac_2867, retro_cjac_3065,
Homo sapiens	ENSG00000144034	1 retrocopy	retro_hsap_552,
Gorilla gorilla	ENSGGOG00000009062	1 retrocopy	retro_ggor_501,
Macaca mulatta	ENSMMUG00000030805	1 retrocopy	retro_mmul_1571,
Monodelphis domestica	ENSMODG00000016950	2 retrocopies	retro_mdom_1264, retro_mdom_465,
Nomascus leucogenys	ENSNLEG00000000300	2 retrocopies	retro_nleu_2021, retro_nleu_957,
Oryctolagus cuniculus	ENSOCUG00000016251	2 retrocopies	retro_ocun_519, retro_ocun_769,
Otolemur garnettii	ENSOGAG00000032893	2 retrocopies	retro_ogar_523, retro_ogar_849,
Pongo abelii	ENSPPYG00000012292	1 retrocopy	retro_pabe_509 ,
Pteropus vampyrus	ENSPVAG00000012419	1 retrocopy	retro_pvam_75,
Ictidomys tridecemlineatus	ENSSTOG00000016406	4 retrocopies	retro_itri_1613, retro_itri_453, retro_itri_918, retro_itri_919,
Tupaia belangeri	ENSTBEG00000014584	2 retrocopies	retro_tbel_33, retro_tbel_3630,
Vicugna pacos	ENSVPAG00000007934	2 retrocopies	retro_vpac_149, retro_vpac_192,