RetrogeneDB ID: retro_ggor_748

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 11:109815797..109816327(-)
• Located in intron of: ENSGGOG00000002519

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: PPIH
• Ensembl ID: ENSGGOG00000022507
• Aliases: None
• Description: Peptidyl-prolyl cis-trans isomerase [Source:UniProtKB/TrEMBL;Acc:G3SD72]

Sequence

>retro_ggor_748
ATGGTGGTGGCAACTTCAAGCCCTGCTAACCCCATGGTGTTCTTTGATGTCAGCAATGGCAGTCAGGAAGTTGGCCGCAC
AAAGATCGAGCTCTCTGCAGACGTTGTGCCTAAGACGACCGAGAACTTTGGGTAGTTCTGCACTAGAGAATTCAGAAAAG
ATGGGGTTCCAATAGGATACAAAGGAAGCACTTTCCACAGGGTCATAAAGGATTTCATGATTTAGGGTGGAGATTTTGTT
AATGGAGATGGTACTGGAGTCACCAGTATTTACCAGGAGACATTTGCAGACGAAAATTTTAAACTTAGACACTCAGCTCC
AGGCCTGCTTTCCACGGCAAACAGCGGTCCCAGTATAAATGGCTGTCAGTTCTTTATCACCTGCTGTAAGTGTGACTGGC
TGGATGGGAAGCATGTAATGTTTGGAAAAATCACTGATGGACTTCTAGTGATGAGAAAGATTGAGAATGTTCCCACAGGC
CCCAAGAATAAGCCCAAACTACTGTGGTGATCTCAAAGTGCAGGGAGATG

Alignment

ORF - retro_ggor_748 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 84.83 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 2
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIK
          M.VA.SSP.NP.VFFDVS.G.QEVGR.KIEL.ADVVPKT.ENF..FCT.EFRKDGVPIGYKGSTFHRVIK
Retrocopy MVVATSSPANPMVFFDVSNGSQEVGRTKIELSADVVPKTTENFG*FCTREFRKDGVPIGYKGSTFHRVIK

Parental  DFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVV
          DFMI.GGDFVNGDGTGV.SIY...FADENFKLRHSAPGLLS.ANSGPS.NGCQFFITC.KCDWLDGKHV.
Retrocopy DFMI*GGDFVNGDGTGVTSIYQETFADENFKLRHSAPGLLSTANSGPSINGCQFFITCCKCDWLDGKHVM

Parental  FGKIIDGLLVMRKIENVPTGPNNKPKL-PVVISQCGEM
          FGKI.DGLLVMRKIENVPTGP.NKPKL..VVIS.C.EM
Retrocopy FGKITDGLLVMRKIENVPTGPKNKPKL<TVVISKCREM

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.05 RPM	13.14 RPM
SRP007412_cerebellum	0.04 RPM	10.40 RPM
SRP007412_heart	0.09 RPM	6.54 RPM
SRP007412_kidney	0.04 RPM	12.84 RPM
SRP007412_liver	0.03 RPM	11.53 RPM
SRP007412_testis	0.21 RPM	15.23 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_748 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_748 has 4 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_928
Pan troglodytes	retro_ptro_644
Pongo abelii	retro_pabe_797
Macaca mulatta	retro_mmul_1124

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Parental genes homology:

Parental genes homology involve 20 parental genes, and 42 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000000526	1 retrocopy	retro_amel_1481,
Bos taurus	ENSBTAG00000004590	1 retrocopy	retro_btau_1530,
Callithrix jacchus	ENSCJAG00000003145	5 retrocopies	retro_cjac_129, retro_cjac_1886, retro_cjac_2205, retro_cjac_3120, retro_cjac_4110,
Cavia porcellus	ENSCPOG00000008214	8 retrocopies	retro_cpor_1511, retro_cpor_785, retro_cpor_786, retro_cpor_794, retro_cpor_795, retro_cpor_796, retro_cpor_797, retro_cpor_798,
Dipodomys ordii	ENSDORG00000016152	3 retrocopies	retro_dord_151, retro_dord_173, retro_dord_447,
Homo sapiens	ENSG00000171960	2 retrocopies	retro_hsap_4740, retro_hsap_928,
Gorilla gorilla	ENSGGOG00000022507	2 retrocopies	retro_ggor_2945, retro_ggor_748 ,
Gorilla gorilla	ENSGGOG00000027071	1 retrocopy	retro_ggor_1630,
Macropus eugenii	ENSMEUG00000001691	1 retrocopy	retro_meug_1699,
Myotis lucifugus	ENSMLUG00000025400	2 retrocopies	retro_mluc_1922, retro_mluc_2243,
Macaca mulatta	ENSMMUG00000013129	1 retrocopy	retro_mmul_1124,
Mustela putorius furo	ENSMPUG00000013966	2 retrocopies	retro_mputfur_285, retro_mputfur_542,
Nomascus leucogenys	ENSNLEG00000012313	2 retrocopies	retro_nleu_1242, retro_nleu_289,
Oryctolagus cuniculus	ENSOCUG00000011453	1 retrocopy	retro_ocun_1195,
Procavia capensis	ENSPCAG00000011139	1 retrocopy	retro_pcap_81,
Pongo abelii	ENSPPYG00000001467	2 retrocopies	retro_pabe_3686, retro_pabe_797,
Pan troglodytes	ENSPTRG00000000614	2 retrocopies	retro_ptro_3155, retro_ptro_644,
Pteropus vampyrus	ENSPVAG00000005500	1 retrocopy	retro_pvam_107,
Ictidomys tridecemlineatus	ENSSTOG00000000115	2 retrocopies	retro_itri_1248, retro_itri_412,
Tarsius syrichta	ENSTSYG00000003182	2 retrocopies	retro_tsyr_224, retro_tsyr_647,