RetrogeneDB ID: retro_pabe_469

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 1:177909147..177909462(-)
• Located in intron of: ENSPPYG00000001357

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: TSEN15
• Ensembl ID: ENSPPYG00000000421
• Aliases: None
• Description: tRNA splicing endonuclease 15 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:16791]

Sequence

>retro_pabe_469
AAATATTTCAAAGTATTTAGAAATGATGTAGTTAGATGTAGGAGATGCATAGCATTCTCAGTTTACCTGGATCTCATGGA
GCATAAAAATTGGCATGAAGTAAACTGTGTTAGATTACCAGAGCCCCAGCTCATCTGCTTTGTCTGTACTGAGACAGAAG
GGGAGGGGTTACAGACTATAGTGCCTACTCCCATCACTGCTTCCCTCAGCCATAACAGGACAAGTGGGATCTTGAAGGCA
TCTTGAAAATTGTAAGGTGATCCAGATTTGGCTGTGTCTTTTACTTTGGCCATAGTGGTGTCCAATTATATTATA

Alignment

ORF - retro_pabe_469 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 66.98 %
• Parental protein coverage: 57.92 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  KYLEMMELDIGDATQVYVAFLVYLDLMESKSWHEVNCVGLPELQLICLVGTEIEGEGLQTVVPTPITASL
          KY......D.........AF.VYLDLME.K.WHEVNCV.LPE.QLIC.V.TE.EGEGLQT.VPTPITASL
Retrocopy KYFKVFRNDVVRCRRC-IAFSVYLDLMEHKNWHEVNCVRLPEPQLICFVCTETEGEGLQTIVPTPITASL

Parental  SHNRIREILKASRKLQGDPDLPMSFTLAIVESDSTI
          SHNR...ILKAS.KL.GDPDL..SFTLAIV.S...I
Retrocopy SHNRTSGILKAS*KL*GDPDLAVSFTLAIVVSNYII

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	0.83 RPM
SRP007412_cerebellum	0.00 RPM	1.09 RPM
SRP007412_heart	0.00 RPM	0.81 RPM
SRP007412_kidney	0.00 RPM	0.76 RPM
SRP007412_liver	0.03 RPM	0.92 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_469 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_469 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_469 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Pan troglodytes	retro_ptro_147
Gorilla gorilla	retro_ggor_240

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Parental genes homology:

Parental genes homology involve 16 parental genes, and 24 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000016369	1 retrocopy	retro_btau_971,
Callithrix jacchus	ENSCJAG00000005356	1 retrocopy	retro_cjac_3055,
Dasypus novemcinctus	ENSDNOG00000017611	2 retrocopies	retro_dnov_1176, retro_dnov_2529,
Homo sapiens	ENSG00000198860	1 retrocopy	retro_hsap_1721,
Gorilla gorilla	ENSGGOG00000015804	2 retrocopies	retro_ggor_2267, retro_ggor_240,
Loxodonta africana	ENSLAFG00000014109	1 retrocopy	retro_lafr_684,
Macaca mulatta	ENSMMUG00000016409	1 retrocopy	retro_mmul_1214,
Mustela putorius furo	ENSMPUG00000011790	1 retrocopy	retro_mputfur_1261,
Mus musculus	ENSMUSG00000014980	1 retrocopy	retro_mmus_2721,
Nomascus leucogenys	ENSNLEG00000018024	1 retrocopy	retro_nleu_98,
Otolemur garnettii	ENSOGAG00000003128	1 retrocopy	retro_ogar_3264,
Pongo abelii	ENSPPYG00000000421	4 retrocopies	retro_pabe_1436, retro_pabe_3065, retro_pabe_3196, retro_pabe_469 ,
Pan troglodytes	ENSPTRG00000023202	2 retrocopies	retro_ptro_1229, retro_ptro_147,
Pteropus vampyrus	ENSPVAG00000001103	1 retrocopy	retro_pvam_1458,
Ictidomys tridecemlineatus	ENSSTOG00000013230	2 retrocopies	retro_itri_1538, retro_itri_1849,
Vicugna pacos	ENSVPAG00000002941	2 retrocopies	retro_vpac_381, retro_vpac_565,