RetrogeneDB ID:

retro_hsap_2133

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:2:104110820..104111696(+)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000236596
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:CRLF3
Ensembl ID:ENSG00000176390
Aliases:CRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2
Description:cytokine receptor-like factor 3 [Source:HGNC Symbol;Acc:17177]


Retrocopy-Parental alignment summary:






>retro_hsap_2133
GAGATCAAAGAGAGTGCATCACAGACAAGCGATGTTCTCAAACAACATTTTCATGATTTAAAGGGAACCCATGGGAAGCT
CCTGGATGAGCGATTGGTGACCCTTTTGCAAGAGGTTGGCACCATTAAACAGACCATTAAACCACTAGATGATTGCCAGA
AGCTCATAGAACACAGAGTTAACACTCCAGAGGGCTTAGTCCAAGAAGATGAGATTGCCATGCTTGGTGGTGTAGAAGAG
AATGAGAAACTGTGGAGCTTTACCAAAAAGGCCTTGCATGTTCAGTTGGACAGCATACCAGAAGTACCTTTACTGGTTGA
TGTGCCTTGTTTATCTGCTCAGTTGGATGAGTGTATTCTTAACATCATGAAAGACCACATTCTTAAGCATGGAACAGTAG
CATCTCGCCCACCAGTACAGATAGAAGAACTGATAGAGAAACCTGGAGGCATCATAGTACAATGGTGTAAGGTGGATGAT
GACTTTACGGCACAAGATGACAGGCTCCAGTTTCGTAAATGTACTTCAAATCGTTTTGAGGATGTATATGTAGGTTCCGA
AACTGAATTCAGAGTATTGCACATAGACTCCAACGTTGAAGATCATTTCAGAATCTGCACCCGAAGAGATGGCTGACAGG
AGCAGAGTCCTTGGAGTGTCCCCCAATTAGTTCATTCCATATCGGAGCCTCATGAGTGGACAGCTGGTTTTGAGAGGAGC
AGTGTGAGCAATGGAAGAAATACGTCATGCCGGAACGATTCTAAATCTTCAGGTGTTCTCAACTCCAGAGCTCCAACTTA
TCTTTCTGGGCAGACATTAATATTTAGAGTTGAAACTGTGGAACTACCAGACAGAAGAGACTGTATAGGAGTGTGC

ORF - retro_hsap_2133 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 81.63 %
Parental protein coverage: 66.52 %
Number of stop codons detected: 1
Number of frameshifts detected 0


Retrocopy - Parental Gene Alignment:

ParentalQIKESASQTRDVLKQHFNDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTAEDLVRE
.IKESASQT.DVLKQHF.DLKGT.GKLLDERLVTLLQEV.TI.Q.TIKPLDDCQKLIEH.VNT.E.LV.E
RetrocopyEIKESASQTSDVLKQHFHDLKGTHGKLLDERLVTLLQEVGTIKQ-TIKPLDDCQKLIEHRVNTPEGLVQE
ParentalGEIAMLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPP
.EIAMLGGV.EENEKLWSFTKKA.H.QLDS.PEVPLLVDVPCLSAQLD..ILNI.KDHI.KHGTVASRPP
RetrocopyDEIAMLGGV-EENEKLWSFTKKALHVQLDSIPEVPLLVDVPCLSAQLDECILNIMKDHILKHGTVASRPP
ParentalVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCAR
VQIEELIEKPGGIIV.WCKVDDDFTAQD.RLQFRKCTSN.FEDVYVGSETEF.VLHID.NV...FR.C.R
RetrocopyVQIEELIEKPGGIIVQWCKVDDDFTAQDDRLQFRKCTSNRFEDVYVGSETEFRVLHIDSNVEDHFRICTR
ParentalGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSESSGVLYSRAPTYFCGQTLTFRVE
.DG.QE.SPWSVPQ..HS...PHEWTAGFE..S.S..RN...RNDS.SSGVL.SRAPTY..GQTL.FRVE
RetrocopyRDG*QEQSPWSVPQLVHSISEPHEWTAGFERSSVSNGRNTSCRNDSKSSGVLNSRAPTYLSGQTLIFRVE
ParentalTVGQPDRRDSIGVC
TV..PDRRD.IGVC
RetrocopyTVELPDRRDCIGVC

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 17 .63 RPM
bodymap2_adrenal 0 .00 RPM 44 .73 RPM
bodymap2_brain 0 .00 RPM 11 .98 RPM
bodymap2_breast 0 .00 RPM 13 .97 RPM
bodymap2_colon 0 .00 RPM 13 .05 RPM
bodymap2_heart 0 .00 RPM 7 .00 RPM
bodymap2_kidney 0 .00 RPM 14 .46 RPM
bodymap2_liver 0 .00 RPM 5 .68 RPM
bodymap2_lung 0 .00 RPM 18 .86 RPM
bodymap2_lymph_node 0 .00 RPM 58 .13 RPM
bodymap2_ovary 0 .00 RPM 23 .04 RPM
bodymap2_prostate 0 .00 RPM 16 .82 RPM
bodymap2_skeletal_muscle 0 .00 RPM 4 .91 RPM
bodymap2_testis 0 .06 RPM 33 .82 RPM
bodymap2_thyroid 0 .00 RPM 9 .08 RPM
bodymap2_white_blood_cells 0 .00 RPM 185 .42 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_2133 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_2133 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_2133 retrocopy 5' end.

Lab - click to see more details

retro_hsap_2133 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_2133 has 4 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Pan troglodytes retro_ptro_1560
Gorilla gorilla retro_ggor_1649
Pongo abelii retro_pabe_1925
Macaca mulatta retro_mmul_1002
Parental genes homology:
Parental genes homology involve 8 parental genes, and 19 retrocopies.

Species Parental gene accession Retrocopies number
Callithrix jacchus ENSCJAG000000141631 retrocopy
retro_cjac_1183,
Homo sapiens ENSG00000176390 3 retrocopies
retro_hsap_2121, retro_hsap_2133 , retro_hsap_3360,
Gorilla gorilla ENSGGOG000000050023 retrocopies
retro_ggor_1644, retro_ggor_1649, retro_ggor_2278,
Macaca mulatta ENSMMUG000000090692 retrocopies
retro_mmul_1002, retro_mmul_998,
Mus musculus ENSMUSG000000175611 retrocopy
retro_mmus_368,
Nomascus leucogenys ENSNLEG000000058504 retrocopies
retro_nleu_1957, retro_nleu_2534, retro_nleu_2899, retro_nleu_2900,
Pongo abelii ENSPPYG000000081423 retrocopies
retro_pabe_1925, retro_pabe_1984, retro_pabe_2672,
Pan troglodytes ENSPTRG000000089632 retrocopies
retro_ptro_1560, retro_ptro_2175,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .00 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .00 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .00 RPM
GBR_HG00111 0 .00 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .00 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .00 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .00 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .00 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).



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