RetrogeneDB ID: retro_mmul_2193

Retrocopy location

• Organism: Rhesus macaque (Macaca mulatta)
• Coordinates: 7:137985605..137986176(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: METTL5
• Ensembl ID: ENSMMUG00000023054
• Aliases: None
• Description: None

Sequence

>retro_mmul_2193
ATGAAGGAATTAAGGCTTAAGGAACTAGAGAGTTGCCTGCAATAAGTGGATAGATTCGAAAAGGCCAAGCTACTTCTAAA
ACAGTATCCCACCAAGCTTCACATTGCAGCATGTATGCTCTATGCAATCTATAACCCTTACGATGACATTGAAAATGAAG
TTTTTGCAGACCTAGGCTGTAGTTGTGGAATGCTTAGCATCGGAACTGCAGTGTTAGGAGCAGGGTTGTGTGTTGGATTT
GACAGAGATGAAGACGTATTGGAAATATTTAACAGGAATGTGGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATG
TGATGTGTGCCTGTTACCTAACAGGATGTCAAGTCATTTGATACAGTAATTATGAATCCTCCTTTTGGGACCAAAAATAA
TAAAGGGATAGATACGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGAACAGCAGTATATTCTTTACACAAATCCTCAG
AGAACATGTTGAAAAGAAAGCTGCAGAATGGGAAATCAAGATAGATATGATTTCAGAGCTTCAGGATGACCTGCCAGCAT
CATACGAGTTT

Alignment

ORF - retro_mmul_2193 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 79.9 %
• Parental protein coverage: 96.97 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  MKKLRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKVIADLGCGCGVLSIGTA
          MK.LRLKELES.LQ.VD.FEK.KLLL.QYPT..HIAACMLY.I.N.YDDIEN.V.ADLGC.CG.LSIGTA
Retrocopy MKELRLKELESCLQ*VDRFEKAKLLLKQYPTKLHIAACMLYAIYNPYDDIENEVFADLGCSCGMLSIGTA

Parental  MLGAGLCVGFDIDEDALEIFNRNVEEFELTNIDMVQCDVCLLSNRMS-KSFDTVIMNPPFGTKNNKGTDM
          .LGAGLCVGFD.DED.LEIFNRNVEEFELTNIDMVQCDVCLL.NRMS.KSFDTVIMNPPFGTKNNKG.D.
Retrocopy VLGAGLCVGFDRDEDVLEIFNRNVEEFELTNIDMVQCDVCLLPNRMS<KSFDTVIMNPPFGTKNNKGIDT

Parental  AFLKTALEMARTAVYSLHKSSTREHVQKKAAEWK-IKIDIIAELRYDLPASYKF
          AFLKTALEMARTAVYSLHKSS.......K....K.IKID.I.EL..DLPASY.F
Retrocopy AFLKTALEMARTAVYSLHKSS-ENMLKRKLQNGK<IKIDMISELQDDLPASYEF

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.00 RPM	3.14 RPM
SRP007412_brain_prefrontal_cortex	0.00 RPM	2.38 RPM
SRP007412_cerebellum	0.00 RPM	3.68 RPM
SRP007412_heart	0.00 RPM	3.95 RPM
SRP007412_kidney	0.00 RPM	6.22 RPM
SRP007412_liver	0.00 RPM	2.93 RPM
SRP007412_testis	0.00 RPM	4.11 RPM

ChIP-Seq

Macaca mulatta was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_mmul_2193 retrocopy.

TSS

Macaca mulatta was not studied using FANTOM5 data.

Lab

retro_mmul_2193 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmul_2193 has 4 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1365
Pan troglodytes	retro_ptro_938
Gorilla gorilla	retro_ggor_1064
Callithrix jacchus	retro_cjac_729

---

Parental genes homology:

Parental genes homology involve 10 parental genes, and 22 retrocopies.

Species	Parental gene accession	Retrocopies number
Cavia porcellus	ENSCPOG00000003343	1 retrocopy	retro_cpor_373,
Dasypus novemcinctus	ENSDNOG00000013460	2 retrocopies	retro_dnov_1043, retro_dnov_773,
Homo sapiens	ENSG00000138382	2 retrocopies	retro_hsap_1365, retro_hsap_2930,
Gorilla gorilla	ENSGGOG00000022484	2 retrocopies	retro_ggor_1064, retro_ggor_2032,
Loxodonta africana	ENSLAFG00000018044	2 retrocopies	retro_lafr_1213, retro_lafr_864,
Macaca mulatta	ENSMMUG00000023054	3 retrocopies	retro_mmul_1430, retro_mmul_1953, retro_mmul_2193 ,
Nomascus leucogenys	ENSNLEG00000005018	4 retrocopies	retro_nleu_1070, retro_nleu_1919, retro_nleu_753, retro_nleu_990,
Oryctolagus cuniculus	ENSOCUG00000010405	1 retrocopy	retro_ocun_1440,
Pongo abelii	ENSPPYG00000012916	2 retrocopies	retro_pabe_2281, retro_pabe_2523,
Pan troglodytes	ENSPTRG00000012621	3 retrocopies	retro_ptro_1822, retro_ptro_2062, retro_ptro_938,