RetrogeneDB ID: retro_mmus_1884

Retrocopy location

• Organism: Mouse (Mus musculus)
• Coordinates: 2:5283649..5284058(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSMUSG00000080820
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: Tomm22
• Ensembl ID: ENSMUSG00000022427
• Aliases: Tomm22, 2310047D01, Tom22
• Description: translocase of outer mitochondrial membrane 22 homolog (yeast) [Source:MGI Symbol;Acc:MGI:2450248]

Sequence

>retro_mmus_1884
ATGGCTACCACCTCCGCTGCAGCTCGCCCTGAGGAGCCTCTGCCCCCCAAAGAATTACTCCCGAAAGCCAAGACACAGAA
GAATGAGGGGGAGCTGGAAGAGGACAAGGCTGGCGAGCTAGGTGAGACCCCGTTAGAGAGACTCTGGGGTCTGACGGAGA
TGTTTCCTGAGAGGGTCTGGTCAGCTGCTGGAGCCACCTTGTTCTTTGTGACCGAGAAGATGCATAGATTTTTCCAGGGC
AACTCTGTGGATTGGGACCACTTCCTGCATGGTCCTGGTTCGCTCTGTTGTCTTTTGAGACAGAAAAGGTGCAAATGGAG
CAACAACAGCAACAGCAGATACTTTTAGGGCCTAACACAGGCTGTCAGGAAGAATGCCAGGGGCTCTACCTCTGCTTCCT
GGAAAGATC

Alignment

ORF - retro_mmus_1884 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 69.66 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 0
• Number of frameshifts detected: 3

Retrocopy - Parental Gene Alignment:

Parental  MAAAVAAAGAGEPLSPEELLPKAEAEKAEEELEEDDDDELDETLSERLWGLTEMFPERVRSAAGATFDLS
          MA...AAA...EPL.P.ELLPKA...K.E.ELEED...EL.ET..ERLWGLTEMFPERV.SAAGAT....
Retrocopy MATTSAAARPEEPLPPKELLPKAKTQKNEGELEEDKAGELGETPLERLWGLTEMFPERVWSAAGATL---

Parental  LFVAQKMYR-FSRAALWIGTTSFMILVLPVV-FETEKLQMEQQQQLQQRQILLGPNTG-LSGGMPGALPP
          .FV..KM.R.FSRA.LWIGTTS.M.LV..VV.FETEK.QMEQQQQ....QILLGPNTG.LSG.MPGALP.
Retrocopy FFVTEKMHR>FSRATLWIGTTSCMVLVRSVV>FETEKVQMEQQQQ---QQILLGPNTG<LSGRMPGALPL

Parental  LPGKM
          LPGK.
Retrocopy LPGKI

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.00 RPM	29.23 RPM
SRP007412_cerebellum	0.00 RPM	18.63 RPM
SRP007412_heart	0.00 RPM	30.26 RPM
SRP007412_kidney	0.00 RPM	24.52 RPM
SRP007412_liver	0.00 RPM	19.69 RPM
SRP007412_testis	0.05 RPM	84.07 RPM

ChIP-Seq

RNA Polymerase II actvity near the 5' end of retro_mmus_1884 was not detected

EST

No EST(s) were mapped for retro_mmus_1884 retrocopy.

TSS

No TSS is located nearby retro_mmus_1884 retrocopy 5' end.

Lab

retro_mmus_1884 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmus_1884 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Rattus norvegicus	retro_rnor_1323

---

Parental genes homology:

Parental genes homology involve 23 parental genes, and 85 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000010692	3 retrocopies	retro_amel_542, retro_amel_58, retro_amel_867,
Canis familiaris	ENSCAFG00000001383	2 retrocopies	retro_cfam_1817, retro_cfam_197,
Callithrix jacchus	ENSCJAG00000011731	5 retrocopies	retro_cjac_1220, retro_cjac_1230, retro_cjac_3675, retro_cjac_498, retro_cjac_94,
Cavia porcellus	ENSCPOG00000005963	1 retrocopy	retro_cpor_754,
Equus caballus	ENSECAG00000010359	1 retrocopy	retro_ecab_334,
Erinaceus europaeus	ENSEEUG00000006428	1 retrocopy	retro_eeur_29,
Echinops telfairi	ENSETEG00000000544	7 retrocopies	retro_etel_123, retro_etel_1477, retro_etel_154, retro_etel_1753, retro_etel_190, retro_etel_2025, retro_etel_599,
Homo sapiens	ENSG00000100216	6 retrocopies	retro_hsap_1249, retro_hsap_2875, retro_hsap_3003, retro_hsap_4928, retro_hsap_633, retro_hsap_907,
Gorilla gorilla	ENSGGOG00000013230	4 retrocopies	retro_ggor_3084, retro_ggor_554, retro_ggor_734, retro_ggor_980,
Macropus eugenii	ENSMEUG00000002901	1 retrocopy	retro_meug_855,
Microcebus murinus	ENSMICG00000011792	3 retrocopies	retro_mmur_1549, retro_mmur_408, retro_mmur_892,
Myotis lucifugus	ENSMLUG00000003761	2 retrocopies	retro_mluc_2116, retro_mluc_543,
Macaca mulatta	ENSMMUG00000000364	8 retrocopies	retro_mmul_1020, retro_mmul_1113, retro_mmul_1459, retro_mmul_241, retro_mmul_2426, retro_mmul_2438, retro_mmul_2532, retro_mmul_498,
Mustela putorius furo	ENSMPUG00000013156	2 retrocopies	retro_mputfur_1038, retro_mputfur_1254,
Mus musculus	ENSMUSG00000022427	2 retrocopies	retro_mmus_1884 , retro_mmus_2496,
Nomascus leucogenys	ENSNLEG00000015159	6 retrocopies	retro_nleu_2116, retro_nleu_2142, retro_nleu_2249, retro_nleu_375, retro_nleu_454, retro_nleu_617,
Otolemur garnettii	ENSOGAG00000029583	9 retrocopies	retro_ogar_1153, retro_ogar_1294, retro_ogar_1905, retro_ogar_2022, retro_ogar_2067, retro_ogar_214, retro_ogar_3111, retro_ogar_3328, retro_ogar_792,
Pongo abelii	ENSPPYG00000011825	6 retrocopies	retro_pabe_1041, retro_pabe_1088, retro_pabe_1968, retro_pabe_2489, retro_pabe_563, retro_pabe_782,
Pan troglodytes	ENSPTRG00000014374	6 retrocopies	retro_ptro_1583, retro_ptro_2031, retro_ptro_2117, retro_ptro_461, retro_ptro_627, retro_ptro_860,
Rattus norvegicus	ENSRNOG00000014058	4 retrocopies	retro_rnor_1323, retro_rnor_2280, retro_rnor_548, retro_rnor_549,
Sus scrofa	ENSSSCG00000000097	1 retrocopy	retro_sscr_310,
Tupaia belangeri	ENSTBEG00000015683	4 retrocopies	retro_tbel_1810, retro_tbel_2901, retro_tbel_2922, retro_tbel_3041,
Vicugna pacos	ENSVPAG00000001485	1 retrocopy	retro_vpac_586,