RetrogeneDB ID: retro_mmul_2477

Retrocopy location

• Organism: Rhesus macaque (Macaca mulatta)
• Coordinates: X:19525864..19527055(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: MMU.2487
• Ensembl ID: ENSMMUG00000007740
• Aliases: None
• Description: None

Sequence

>retro_mmul_2477
ATGGTGAAAGAAACAACTTACTACAATGTTTTGGAGGTCAAACCCAATGCTACTCAGGAAGAACTGAAAAAGGCTTATAG
GAAACTGGTCTTGAAGTACCATCCTGATAAGAATCCAAATGAAGGAGAGAAGTTTAAACAGATTTCTCAAGCTTACGAAG
TTCTCTCTGATGCAAAAGAAAAGGGAATTATATGACAAAGGAGGATAACAGGCAATTAAAGAGGGTGGAGCAAGTGGCGG
TTTTGGTTCCCCCATGGACATCTTTGATATGTTTTTTGGAGGAGGAGGAAGGATGCAGAGAGAAAGGAGAGTCAAAAATA
TTGTACATCAGCTCTCAGTAACCCTAGAAGACTTATATAATGGTACAACAATAAAACTGGCTCTGCAAAAGAATGTGATT
TGTGACAAATGTGAAGGTAGAGGAGGTAAGAAAGGAGCAGTAGAGGGCTGCCCCAATTGCTGAGGTACTGCAATGCAAAT
AAGAATTCATCAGATAAGATCTGGAATGGTTCAGCAAATTCAATCTGTGTGCATGGAGTGCCAGGGCCATGGGGAGCAGA
TCAGTCCTAAAGATAGATGTAAAAGCTGCAATGGAAGGAAGATAGCTCGAGAGAAGAAGATTCTAGAAGTTCATATTGAC
AAAGGCATGAAAGATGGCCAGAAGATAACATTCCATGGTGAAGGAGACCAAGAACCAGGACTGGAGCCAGGCGGTATTAT
CATTGTGTTAGATCAGAAGGACCATCTGTTTTTACTTGACGAGGAGAAGACTTTTTCATGTGTATGAACATACGGCTGGT
TGAAGCATTGTGTGGCTTCCAGAAGCCAATATCTACTCTTGACAACCGAACCATAGTCATCACCTCTCATCTAGGTCAGA
CTGTCAAGCATGGAGATATCAAGTGTGTACTAAATGAAGGCATGCCAATTTATCATAGACCATATGAAAAGGGTCGCCTA
ATCATTGAATTTAAGGTAAACTTTCCTGAGAATGGCTTTCTCTCTCCTGATAAACTGTCTTTGCTGGAAAAACTCCTACC
AGAGAGGAAGGAAATGGAAGAGACTGATGAGATGGATCAAGTAGAACTGGTGGACTTTGATCCAAATCAGGAAAGATGGC
GCCATTACAATGGAGAAGCATATGAGGATAATGAACATCATCCCAGAGGTGGTGTTCAGTGTCAGACCTCT

Alignment

ORF - retro_mmul_2477 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 92.48 %
• Parental protein coverage: 100.0 %
• Number of stop codons detected: 3
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAK-KRELYDKGGE
          MVKETTYY.VL.VKPNATQEELKKAYRKL.LKYHPDKNPNEGEKFKQISQAYEVLSDAK.KRELYDKGG.
Retrocopy MVKETTYYNVLEVKPNATQEELKKAYRKLVLKYHPDKNPNEGEKFKQISQAYEVLSDAK>KRELYDKGG*

Parental  QAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEG
          QAIKEGGA.GGFGSPMDIFDMFFGGGGRMQRERR.KN.VHQLSVTLEDLYNG.T.KLALQKNVICDKCEG
Retrocopy QAIKEGGASGGFGSPMDIFDMFFGGGGRMQRERRVKNIVHQLSVTLEDLYNGTTIKLALQKNVICDKCEG

Parental  RGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILE
          RGGKKGAVE.CPNC.GT.MQIRIHQI..GMVQQIQSVCMECQGHGE.ISPKDRCKSCNGRKI.REKKILE
Retrocopy RGGKKGAVEGCPNC*GTAMQIRIHQIRSGMVQQIQSVCMECQGHGEQISPKDRCKSCNGRKIAREKKILE

Parental  VHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDH-AVFTRRGEDLFMCMDIQLVEALCGFQKPIS
          VHIDKGMKDGQKITFHGEGDQEPGLEPG.IIIVLDQKDH..VFT.RGED.FMCM.I.LVEALCGFQKPIS
Retrocopy VHIDKGMKDGQKITFHGEGDQEPGLEPGGIIIVLDQKDH<SVFT*RGEDFFMCMNIRLVEALCGFQKPIS

Parental  TLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPE
          TLDNRTIVITSH.GQ.VKHGDIKCVLNEGMPIY.RPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPE
Retrocopy TLDNRTIVITSHLGQTVKHGDIKCVLNEGMPIYHRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPE

Parental  RKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
          RKE.EETDEMDQVELVDFDPNQER.RHYNGEAYED.EHHPRGGVQCQTS
Retrocopy RKEMEETDEMDQVELVDFDPNQERWRHYNGEAYEDNEHHPRGGVQCQTS

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	1.23 RPM	212.00 RPM
SRP007412_brain_prefrontal_cortex	0.32 RPM	192.85 RPM
SRP007412_cerebellum	0.90 RPM	107.58 RPM
SRP007412_heart	0.47 RPM	79.67 RPM
SRP007412_kidney	0.47 RPM	94.25 RPM
SRP007412_liver	0.32 RPM	82.02 RPM
SRP007412_testis	10.82 RPM	424.47 RPM

ChIP-Seq

Macaca mulatta was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_mmul_2477 retrocopy.

TSS

Macaca mulatta was not studied using FANTOM5 data.

Lab

retro_mmul_2477 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmul_2477 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 11 parental genes, and 58 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000007589	4 retrocopies	retro_amel_1509, retro_amel_455, retro_amel_756, retro_amel_946,
Canis familiaris	ENSCAFG00000001818	23 retrocopies	retro_cfam_1111, retro_cfam_1153, retro_cfam_1218, retro_cfam_1229, retro_cfam_1315, retro_cfam_1352, retro_cfam_1420, retro_cfam_1457, retro_cfam_1520, retro_cfam_1668, retro_cfam_1833, retro_cfam_1941, retro_cfam_1949, retro_cfam_1994, retro_cfam_2004, retro_cfam_2162, retro_cfam_352, retro_cfam_391, retro_cfam_419, retro_cfam_749, retro_cfam_751, retro_cfam_923, retro_cfam_993,
Felis catus	ENSFCAG00000008729	5 retrocopies	retro_fcat_1241, retro_fcat_1407, retro_fcat_1502, retro_fcat_1984, retro_fcat_811,
Gorilla gorilla	ENSGGOG00000007030	3 retrocopies	retro_ggor_1603, retro_ggor_2463, retro_ggor_418,
Macaca mulatta	ENSMMUG00000002247	1 retrocopy	retro_mmul_36,
Macaca mulatta	ENSMMUG00000007740	6 retrocopies	retro_mmul_1313, retro_mmul_1802, retro_mmul_2477 , retro_mmul_2482, retro_mmul_2625, retro_mmul_400,
Monodelphis domestica	ENSMODG00000003384	7 retrocopies	retro_mdom_1140, retro_mdom_1253, retro_mdom_1451, retro_mdom_1627, retro_mdom_1824, retro_mdom_742, retro_mdom_874,
Nomascus leucogenys	ENSNLEG00000005268	4 retrocopies	retro_nleu_1255, retro_nleu_2550, retro_nleu_2793, retro_nleu_509,
Oryctolagus cuniculus	ENSOCUG00000004833	2 retrocopies	retro_ocun_516, retro_ocun_70,
Sarcophilus harrisii	ENSSHAG00000012366	1 retrocopy	retro_shar_762,
Sus scrofa	ENSSSCG00000011000	2 retrocopies	retro_sscr_134, retro_sscr_984,