RetrogeneDB ID: retro_mmus_2242

Retrocopy location

• Organism: Mouse (Mus musculus)
• Coordinates: 3:40901886..40902336(-)
• Located in intron of: ENSMUSG00000037818

Retrocopy information

• Ensembl ID: ENSMUSG00000074619
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: Fundc2
• Ensembl ID: ENSMUSG00000031198
• Aliases: None
• Description: FUN14 domain containing 2 [Source:MGI Symbol;Acc:MGI:1914641]

Sequence

>retro_mmus_2242
ATGGCCTCGGCCAGTCAAGGGCATTTTGATGCTTACGAGGCACTGGATCTTACAGAATTTGCCAAAAAACAGCCTTGGTG
GCGCAAGCTTTTCGGGCAGGAGAGTCGGTCTGCAGGTGAGAAGTACAGTGTGGCAACCCAGCTCCTTATTGGAGGTGTCA
CTGGCTGGTGCACTGGCTTCATATTCCAGAAAGTTGGAAAGCTGGCTGCCACAGCAGTGGGAGGGGGCTTTTTTCTCCTC
CAGCTTGCAAACCACACTGGCTACATCAAAGTTGACTGGAGTCGAGTAGAGAAGGACATGAAAAAGGCCAAGGAGCAGCT
GACAATTCGGAAGAGCGCCCAAATACCAACTGAAGTCAAGAGCAAAGCTGAGGAGGTGGTGTGCTTTGTGAAGAAGAATG
TTTTAGTAACTGGAGGATTTTTTGGAGGCTTTCTGCTCGGTATGGCATCC

Alignment

ORF - retro_mmus_2242 Open Reading Frame is conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 86.75 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 0
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  MAANSQGNFDGKFEALDLAELTKKQPWWRKLFGQESGPSAEKYSVATQLVIGGVTGWCTGFVFQKVGKLA
          MA..SQG.FD...EALDL.E..KKQPWWRKLFGQES....EKYSVATQL.IGGVTGWCTGF.FQKVGKLA
Retrocopy MASASQGHFDA-YEALDLTEFAKKQPWWRKLFGQESRSAGEKYSVATQLLIGGVTGWCTGFIFQKVGKLA

Parental  ATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKNKQIPTEVKSKAEEVVSFVKKNVLVTGG
          ATAVGGGFFLLQLANHTGYIKVDW.RVEKDMKKAKEQL.IRK..QIPTEVKSKAEEVV.FVKKNVLVTGG
Retrocopy ATAVGGGFFLLQLANHTGYIKVDWSRVEKDMKKAKEQLTIRKSAQIPTEVKSKAEEVVCFVKKNVLVTGG

Parental  FFGGFLLGMAS
          FFGGFLLGMAS
Retrocopy FFGGFLLGMAS

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.00 RPM	29.18 RPM
SRP007412_cerebellum	0.00 RPM	24.06 RPM
SRP007412_heart	0.00 RPM	79.63 RPM
SRP007412_kidney	0.00 RPM	46.91 RPM
SRP007412_liver	0.00 RPM	2.87 RPM
SRP007412_testis	3.29 RPM	2.42 RPM

ChIP-Seq

RNA Polymerase II actvity near the 5' end of retro_mmus_2242 was not detected

EST

No EST(s) were mapped for retro_mmus_2242 retrocopy.

TSS

No TSS is located nearby retro_mmus_2242 retrocopy 5' end.

Lab

retro_mmus_2242 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmus_2242 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Rattus norvegicus	retro_rnor_1648

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Parental genes homology:

Parental genes homology involve 19 parental genes, and 49 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000016977	1 retrocopy	retro_btau_292,
Choloepus hoffmanni	ENSCHOG00000004306	11 retrocopies	retro_chof_1501, retro_chof_161, retro_chof_1640, retro_chof_1674, retro_chof_2087, retro_chof_2351, retro_chof_2355, retro_chof_2396, retro_chof_2491, retro_chof_2519, retro_chof_580,
Callithrix jacchus	ENSCJAG00000004287	3 retrocopies	retro_cjac_1977, retro_cjac_2387, retro_cjac_651,
Dipodomys ordii	ENSDORG00000013156	1 retrocopy	retro_dord_597,
Echinops telfairi	ENSETEG00000013817	2 retrocopies	retro_etel_1724, retro_etel_435,
Homo sapiens	ENSG00000165775	3 retrocopies	retro_hsap_2122, retro_hsap_2560, retro_hsap_3530,
Loxodonta africana	ENSLAFG00000015289	1 retrocopy	retro_lafr_2,
Myotis lucifugus	ENSMLUG00000007776	1 retrocopy	retro_mluc_219,
Macaca mulatta	ENSMMUG00000010248	1 retrocopy	retro_mmul_78,
Monodelphis domestica	ENSMODG00000016484	1 retrocopy	retro_mdom_1736,
Mus musculus	ENSMUSG00000031198	2 retrocopies	retro_mmus_2241, retro_mmus_2242 ,
Nomascus leucogenys	ENSNLEG00000014443	5 retrocopies	retro_nleu_1512, retro_nleu_1662, retro_nleu_1958, retro_nleu_2386, retro_nleu_494,
Otolemur garnettii	ENSOGAG00000033461	3 retrocopies	retro_ogar_1146, retro_ogar_132, retro_ogar_762,
Pongo abelii	ENSPPYG00000020897	4 retrocopies	retro_pabe_1884, retro_pabe_2646, retro_pabe_2916, retro_pabe_49,
Pan troglodytes	ENSPTRG00000041852	4 retrocopies	retro_ptro_1490, retro_ptro_1553, retro_ptro_2254, retro_ptro_2398,
Pteropus vampyrus	ENSPVAG00000013552	1 retrocopy	retro_pvam_210,
Rattus norvegicus	ENSRNOG00000024066	2 retrocopies	retro_rnor_1648, retro_rnor_2870,
Sus scrofa	ENSSSCG00000012817	1 retrocopy	retro_sscr_274,
Ictidomys tridecemlineatus	ENSSTOG00000007801	2 retrocopies	retro_itri_1157, retro_itri_1399,