RetrogeneDB ID: retro_mmus_2757

Retrocopy location

• Organism: Mouse (Mus musculus)
• Coordinates: 6:85843979..85844459(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSMUSG00000040078
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: Ptges3
• Ensembl ID: ENSMUSG00000071072
• Aliases: Ptges3, 5730442A20Rik, Ptges, Tebp, cPGES, p23, sid3177
• Description: prostaglandin E synthase 3 (cytosolic) [Source:MGI Symbol;Acc:MGI:1929282]

Sequence

>retro_mmus_2757
ATGCAGCCTGCTTCTGCAAAGTGGTACGATCGAAGGGACTATGTATTCATTGAATTTTGTGTTGAAGACAGTAAAGATGT
TAATGTAAACTTTGAAAAATCCAAACTTACTTTCAGTTGTCTTGGAGGAAGCGATAATTTTAAGCATTTAAATGAAATTG
ATCTTTTTCATTGTATCGATCCAAATGATTCCAAGCATAAAAGAACAGACAGATCGATTTTATGTTGTTTGCGAAAAGGA
GAATCCGGCCAGTCATGGCCTAGGTTAACAAAGGAAAGGGCAAAGCTTAATTGGCTCAGTGTGGACTTCAATAATTGGAA
AGACTGGGAGGATGACTCAGATGAAGACATGTCGAATTTTGACCGTTTCTCTGAGATGATGGATCACATGGGTGGTGATG
AGGATGTAGATTTACCAGAAGTAGATGGAGCAGATGATGATTCACAAGACAGTGATGATGAAAAGATGCCAGATCTGGAG

Alignment

ORF - retro_mmus_2757 Open Reading Frame is conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 100. %
• Parental protein coverage: 100. %
• Number of stop codons detected: 0
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTD
          MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTD
Retrocopy MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTD

Parental  RSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMDHMGGDEDVDLPE
          RSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMDHMGGDEDVDLPE
Retrocopy RSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMDHMGGDEDVDLPE

Parental  VDGADDDSQDSDDEKMPDLE
          VDGADDDSQDSDDEKMPDLE
Retrocopy VDGADDDSQDSDDEKMPDLE

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	1.33 RPM	35.91 RPM
SRP007412_cerebellum	1.69 RPM	29.92 RPM
SRP007412_heart	1.06 RPM	21.36 RPM
SRP007412_kidney	2.44 RPM	37.94 RPM
SRP007412_liver	2.08 RPM	40.25 RPM
SRP007412_testis	3.61 RPM	59.87 RPM

ChIP-Seq

RNA Polymerase II actvity near the 5' end of retro_mmus_2757 was not detected

EST

1 EST(s) were mapped to retro_mmus_2757 retrocopy

EST ID	Start	End	Identity	Match	Mis-match	Score
CX222947	85844141	85844282	97.9	141	0	140

TSS

No TSS is located nearby retro_mmus_2757 retrocopy 5' end.

Lab

retro_mmus_2757 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmus_2757 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 24 parental genes, and 86 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000004172	1 retrocopy	retro_amel_1835,
Bos taurus	ENSBTAG00000017967	2 retrocopies	retro_btau_1766, retro_btau_275,
Choloepus hoffmanni	ENSCHOG00000006514	1 retrocopy	retro_chof_1336,
Callithrix jacchus	ENSCJAG00000010724	6 retrocopies	retro_cjac_1001, retro_cjac_1304, retro_cjac_2122, retro_cjac_3826, retro_cjac_473, retro_cjac_942,
Cavia porcellus	ENSCPOG00000000057	2 retrocopies	retro_cpor_183, retro_cpor_523,
Dasypus novemcinctus	ENSDNOG00000011310	4 retrocopies	retro_dnov_2088, retro_dnov_2571, retro_dnov_472, retro_dnov_969,
Dipodomys ordii	ENSDORG00000000964	2 retrocopies	retro_dord_600, retro_dord_94,
Echinops telfairi	ENSETEG00000000024	1 retrocopy	retro_etel_1612,
Homo sapiens	ENSG00000110958	5 retrocopies	retro_hsap_2084, retro_hsap_3122, retro_hsap_417, retro_hsap_618, retro_hsap_623,
Gorilla gorilla	ENSGGOG00000027957	5 retrocopies	retro_ggor_111, retro_ggor_135, retro_ggor_154, retro_ggor_542, retro_ggor_546,
Loxodonta africana	ENSLAFG00000008268	1 retrocopy	retro_lafr_490,
Macropus eugenii	ENSMEUG00000001288	1 retrocopy	retro_meug_264,
Myotis lucifugus	ENSMLUG00000015927	3 retrocopies	retro_mluc_1111, retro_mluc_2120, retro_mluc_836,
Macaca mulatta	ENSMMUG00000013766	6 retrocopies	retro_mmul_1054, retro_mmul_1988, retro_mmul_2239, retro_mmul_2421, retro_mmul_679, retro_mmul_978,
Mus musculus	ENSMUSG00000071072	2 retrocopies	retro_mmus_2441, retro_mmus_2757 ,
Nomascus leucogenys	ENSNLEG00000017454	3 retrocopies	retro_nleu_2133, retro_nleu_2486, retro_nleu_446,
Otolemur garnettii	ENSOGAG00000028667	3 retrocopies	retro_ogar_1035, retro_ogar_1748, retro_ogar_2858,
Procavia capensis	ENSPCAG00000007779	2 retrocopies	retro_pcap_29, retro_pcap_434,
Pongo abelii	ENSPPYG00000004669	4 retrocopies	retro_pabe_2010, retro_pabe_2579, retro_pabe_5, retro_pabe_553,
Pan troglodytes	ENSPTRG00000005108	8 retrocopies	retro_ptro_1533, retro_ptro_1945, retro_ptro_2111, retro_ptro_2926, retro_ptro_319, retro_ptro_452, retro_ptro_454, retro_ptro_609,
Rattus norvegicus	ENSRNOG00000002642	5 retrocopies	retro_rnor_1011, retro_rnor_119, retro_rnor_1836, retro_rnor_1931, retro_rnor_2895,
Sorex araneus	ENSSARG00000007751	2 retrocopies	retro_sara_489, retro_sara_507,
Tupaia belangeri	ENSTBEG00000002994	15 retrocopies	retro_tbel_1658, retro_tbel_2266, retro_tbel_2370, retro_tbel_2383, retro_tbel_2598, retro_tbel_2622, retro_tbel_2823, retro_tbel_3798, retro_tbel_402, retro_tbel_407, retro_tbel_4279, retro_tbel_4432, retro_tbel_4461, retro_tbel_450, retro_tbel_997,
Tarsius syrichta	ENSTSYG00000009622	2 retrocopies	retro_tsyr_1264, retro_tsyr_177,