RetrogeneDB ID: retro_mmus_2207

Retrocopy location

• Organism: Mouse (Mus musculus)
• Coordinates: 3:144727883..144728447(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: Bnip3
• Ensembl ID: ENSMUSG00000078566
• Aliases: Bnip3, Nip3
• Description: BCL2/adenovirus E1B interacting protein 3 [Source:MGI Symbol;Acc:MGI:109326]

Sequence

>retro_mmus_2207
ATGTCGCAGAGTGGGGAGGAGAACCTGCAGGGCTCCTGGGTAGAACTGCACTTCAGCAATTCCAATGGGAGCAGCGTTCC
AGCCTCCATCTCTATTTATAATGGCGACATGGAAAAAATACTGTTGGATGCCCAGCATGAATCTGGACGAAGTAGCTCCA
AGAGTTCTCACTGTGACAGCCCACCTTGCTCCCAGACATCACAAGATACCAACAGAGCTGAAAGAGACACACCCACAGCT
ATGGCGAGAAAAACAGCACTTTGTCTGAGGAAGATTATATTGAGAGAAGAAGAGAAGTTGAAAGTATCTTGAAGAAAAAC
TCAGATTGAATATGGGGTTGGTCAAGTCGGCCAGAAAATATTCACCCCCAAGGAGTTCCTTTTTAAACACCCGAAGTGCA
CATCTACTCTCATCATGAGAAACACAAGCATTATGAAGAAAGGGGGAATTTTCTCAGCAGACTTTCTGAAGGTTTTCCTT
CCATTTCAGTTACTGTCTCATCTGCTGGCCATTGGCTTGGGGACCTACATTGGAAGGCGTCTGACAACTTCCATTGGCAC
CTTC

Alignment

ORF - retro_mmus_2207 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 81.05 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 1
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  MSQSGEENLQGSWVELHFSNGNGSSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDT
          MSQSGEENLQGSWVELHFSN.NGSSVPAS.SIYNGDMEKILLDAQHESGRSSSKSSHCDSPP.SQT.QDT
Retrocopy MSQSGEENLQGSWVELHFSNSNGSSVPASISIYNGDMEKILLDAQHESGRSSSKSSHCDSPPCSQTSQDT

Parental  NRAEIDSHSFGEKNSTLSEEDYIER-RR-EVESILKKNSDWIWDWSSRPENI-PPKEFLFKHPKRTATLS
          NRAE.D..........L.....I.R.RR.EVESILKKNSD.IW.WSSRPENI..PKEFLFKHPK.T.TL.
Retrocopy NRAERDTPTAMARKTALCLRKIILR<RRREVESILKKNSD*IWGWSSRPENI>TPKEFLFKHPKCTSTLI

Parental  MRNTSVMKKGGIFSADFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF
          MRNTS.MKKGGIFSADFLKVFLP..LLSHLLAIGLG.YIGRRLTTS..TF
Retrocopy MRNTSIMKKGGIFSADFLKVFLPFQLLSHLLAIGLGTYIGRRLTTSIGTF

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.05 RPM	33.78 RPM
SRP007412_cerebellum	0.17 RPM	19.54 RPM
SRP007412_heart	0.00 RPM	34.27 RPM
SRP007412_kidney	0.06 RPM	47.76 RPM
SRP007412_liver	0.00 RPM	76.08 RPM
SRP007412_testis	0.09 RPM	3.61 RPM

ChIP-Seq

RNA Polymerase II actvity near the 5' end of retro_mmus_2207 was not detected

EST

No EST(s) were mapped for retro_mmus_2207 retrocopy.

TSS

TSS No.	TSS Name	TSS expression level (Expr) in TPM range:
		no expression	0 < Expr ≤ 1	1 < Expr ≤ 5	5 < Expr ≤ 10	Expr > 10
TSS #1	TSS_93135	355 libraries	318 libraries	293 libraries	69 libraries	37 libraries

The graphical summary, for retro_mmus_2207 TSS expression levels > 0 TPM .
TSS expression levels were studied across 1072 TSS-CAGE libraries, based on FANTOM5 data.
The expression values were visualized using beanplot. If you have any doubts, how to read it, read more in Kampstra P (2008)

Lab

retro_mmus_2207 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmus_2207 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 20 parental genes, and 148 retrocopies.

Species	Parental gene accession	Retrocopies number
Choloepus hoffmanni	ENSCHOG00000002150	2 retrocopies	retro_chof_1555, retro_chof_559,
Callithrix jacchus	ENSCJAG00000000228	8 retrocopies	retro_cjac_1882, retro_cjac_2068, retro_cjac_2105, retro_cjac_2106, retro_cjac_2107, retro_cjac_2108, retro_cjac_3953, retro_cjac_4031,
Cavia porcellus	ENSCPOG00000005882	7 retrocopies	retro_cpor_1138, retro_cpor_1283, retro_cpor_344, retro_cpor_376, retro_cpor_496, retro_cpor_600, retro_cpor_647,
Dipodomys ordii	ENSDORG00000012511	1 retrocopy	retro_dord_431,
Equus caballus	ENSECAG00000017458	3 retrocopies	retro_ecab_652, retro_ecab_921, retro_ecab_969,
Echinops telfairi	ENSETEG00000011704	1 retrocopy	retro_etel_1779,
Homo sapiens	ENSG00000176171	21 retrocopies	retro_hsap_1308, retro_hsap_1486, retro_hsap_1976, retro_hsap_1979, retro_hsap_1980, retro_hsap_1983, retro_hsap_1985, retro_hsap_1986, retro_hsap_1988, retro_hsap_1990, retro_hsap_2035, retro_hsap_2036, retro_hsap_2039, retro_hsap_2040, retro_hsap_2042, retro_hsap_2043, retro_hsap_2044, retro_hsap_2046, retro_hsap_3741, retro_hsap_3743, retro_hsap_3858,
Gorilla gorilla	ENSGGOG00000014520	17 retrocopies	retro_ggor_1138, retro_ggor_1433, retro_ggor_1434, retro_ggor_1436, retro_ggor_1437, retro_ggor_1438, retro_ggor_1439, retro_ggor_1440, retro_ggor_1466, retro_ggor_1467, retro_ggor_1468, retro_ggor_1469, retro_ggor_1472, retro_ggor_1474, retro_ggor_1475, retro_ggor_2521, retro_ggor_2599,
Microcebus murinus	ENSMICG00000011985	1 retrocopy	retro_mmur_563,
Macaca mulatta	ENSMMUG00000022445	13 retrocopies	retro_mmul_1367, retro_mmul_1369, retro_mmul_1371, retro_mmul_1392, retro_mmul_1393, retro_mmul_1394, retro_mmul_1681, retro_mmul_355, retro_mmul_421, retro_mmul_739, retro_mmul_754, retro_mmul_772, retro_mmul_819,
Mus musculus	ENSMUSG00000022051	2 retrocopies	retro_mmus_482, retro_mmus_849,
Mus musculus	ENSMUSG00000078566	4 retrocopies	retro_mmus_1194, retro_mmus_1195, retro_mmus_2207 , retro_mmus_3577,
Nomascus leucogenys	ENSNLEG00000001613	26 retrocopies	retro_nleu_140, retro_nleu_1708, retro_nleu_2220, retro_nleu_2306, retro_nleu_2617, retro_nleu_2619, retro_nleu_2620, retro_nleu_2621, retro_nleu_2870, retro_nleu_2872, retro_nleu_2903, retro_nleu_2904, retro_nleu_2905, retro_nleu_2907, retro_nleu_2910, retro_nleu_2917, retro_nleu_2918, retro_nleu_2919, retro_nleu_2920, retro_nleu_2921, retro_nleu_2923, retro_nleu_2924, retro_nleu_2942, retro_nleu_3064, retro_nleu_3103, retro_nleu_3104,
Pongo abelii	ENSPPYG00000002771	18 retrocopies	retro_pabe_1629, retro_pabe_1631, retro_pabe_1632, retro_pabe_1633, retro_pabe_1665, retro_pabe_1666, retro_pabe_1667, retro_pabe_1670, retro_pabe_1688, retro_pabe_1694, retro_pabe_1703, retro_pabe_2499, retro_pabe_3049, retro_pabe_3050, retro_pabe_3120, retro_pabe_3122, retro_pabe_3533, retro_pabe_3569,
Pan troglodytes	ENSPTRG00000003067	17 retrocopies	retro_ptro_1005, retro_ptro_1317, retro_ptro_1319, retro_ptro_1323, retro_ptro_1324, retro_ptro_1325, retro_ptro_1327, retro_ptro_1353, retro_ptro_1354, retro_ptro_1356, retro_ptro_1357, retro_ptro_1359, retro_ptro_1360, retro_ptro_1361, retro_ptro_1363, retro_ptro_2629, retro_ptro_3062,
Rattus norvegicus	ENSRNOG00000017243	3 retrocopies	retro_rnor_1070, retro_rnor_2645, retro_rnor_2732,
Sus scrofa	ENSSSCG00000024388	1 retrocopy	retro_sscr_827,
Ictidomys tridecemlineatus	ENSSTOG00000012456	1 retrocopy	retro_itri_299,
Tupaia belangeri	ENSTBEG00000000487	1 retrocopy	retro_tbel_2600,
Tursiops truncatus	ENSTTRG00000008038	1 retrocopy	retro_ttru_1538,