RetrogeneDB ID: retro_pabe_621

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 10:97994828..97995165(-)
• Located in intron of: ENSPPYG00000002550

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: ARL5A
• Ensembl ID: ENSPPYG00000012848
• Aliases: None
• Description: ADP-ribosylation factor-like 5A [Source:HGNC Symbol;Acc:696]

Sequence

>retro_pabe_621
CGTTTCCTAATGTGGGATATTGGTGGCCAAGAATCTCTTCGTTCTTCCTGAAACACTTACTGTACTAACACAGAGTCTGT
ATAGTTGTTGTGAACAGTACAGACAGAGAGAGGGTTTCTGTAACTAGAGAACTCTATAAAATGTTAGCACATGAGGACCT
AAGAAAAGCTGGATTGCTGATTTTTGCTAATAAACAAGATGTTAAAAAATGCATAACTGTAGCAGAATCTCCCAGTTTGT
GAAGCTAACATCTATTAAAGATCACCAGTGGCATATCCAGGCATGCTGTTCTCTAACTGGTGAGGGATTGTGCCAAGGAC
TTGAATGGTTGGTCACG

Alignment

ORF - retro_pabe_621 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 87.07 %
• Parental protein coverage: 63.69 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  RFLMWDIGGQESLRSSWNTYYTNTEFV-IVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDV
          RFLMWDIGGQESLRSS.NTY.TNTE.V.IVVV.STDRER.SVTRE.LYKMLAHEDLRKAGLLIFANKQDV
Retrocopy RFLMWDIGGQESLRSS*NTYCTNTESV<IVVVNSTDRERVSVTRE-LYKMLAHEDLRKAGLLIFANKQDV

Parental  KECMTVAE-ISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMS
          K.C.TVAE.ISQF.KLTSIKDHQWHIQACC.LTGEGLCQGLEW...
Retrocopy KKCITVAE<ISQFVKLTSIKDHQWHIQACCSLTGEGLCQGLEWLVT

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	4.98 RPM
SRP007412_cerebellum	0.00 RPM	7.30 RPM
SRP007412_heart	0.00 RPM	5.27 RPM
SRP007412_kidney	0.00 RPM	5.04 RPM
SRP007412_liver	0.00 RPM	4.25 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_621 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_621 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_621 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_721
Pan troglodytes	retro_ptro_514

---

Parental genes homology:

Parental genes homology involve 17 parental genes, and 102 retrocopies.

Species	Parental gene accession	Retrocopies number
Choloepus hoffmanni	ENSCHOG00000005062	25 retrocopies	retro_chof_1109, retro_chof_1132, retro_chof_1205, retro_chof_1218, retro_chof_1407, retro_chof_1414, retro_chof_1443, retro_chof_1573, retro_chof_1712, retro_chof_1953, retro_chof_206, retro_chof_2081, retro_chof_2131, retro_chof_2142, retro_chof_2433, retro_chof_2464, retro_chof_2470, retro_chof_2713, retro_chof_373, retro_chof_547, retro_chof_836, retro_chof_857, retro_chof_865, retro_chof_972, retro_chof_98,
Callithrix jacchus	ENSCJAG00000003311	9 retrocopies	retro_cjac_1054, retro_cjac_1111, retro_cjac_1255, retro_cjac_1921, retro_cjac_2949, retro_cjac_3920, retro_cjac_4131, retro_cjac_4175, retro_cjac_4211,
Cavia porcellus	ENSCPOG00000005209	1 retrocopy	retro_cpor_913,
Dasypus novemcinctus	ENSDNOG00000013331	16 retrocopies	retro_dnov_105, retro_dnov_1165, retro_dnov_1244, retro_dnov_1953, retro_dnov_2159, retro_dnov_226, retro_dnov_2265, retro_dnov_2268, retro_dnov_2344, retro_dnov_2394, retro_dnov_563, retro_dnov_671, retro_dnov_713, retro_dnov_811, retro_dnov_818, retro_dnov_881,
Felis catus	ENSFCAG00000014742	2 retrocopies	retro_fcat_569, retro_fcat_65,
Homo sapiens	ENSG00000162980	5 retrocopies	retro_hsap_2549, retro_hsap_4715, retro_hsap_4768, retro_hsap_4894, retro_hsap_721,
Loxodonta africana	ENSLAFG00000032104	4 retrocopies	retro_lafr_1178, retro_lafr_1228, retro_lafr_1244, retro_lafr_599,
Microcebus murinus	ENSMICG00000015788	7 retrocopies	retro_mmur_1271, retro_mmur_1487, retro_mmur_1586, retro_mmur_1618, retro_mmur_468, retro_mmur_652, retro_mmur_923,
Macaca mulatta	ENSMMUG00000010521	5 retrocopies	retro_mmul_2519, retro_mmul_2543, retro_mmul_2630, retro_mmul_616, retro_mmul_641,
Monodelphis domestica	ENSMODG00000003978	1 retrocopy	retro_mdom_75,
Mus musculus	ENSMUSG00000036093	1 retrocopy	retro_mmus_2232,
Nomascus leucogenys	ENSNLEG00000011191	2 retrocopies	retro_nleu_1259, retro_nleu_2280,
Otolemur garnettii	ENSOGAG00000011424	6 retrocopies	retro_ogar_1879, retro_ogar_2112, retro_ogar_2675, retro_ogar_3146, retro_ogar_3465, retro_ogar_728,
Pongo abelii	ENSPPYG00000012848	4 retrocopies	retro_pabe_3711, retro_pabe_3806, retro_pabe_3832, retro_pabe_621 ,
Pan troglodytes	ENSPTRG00000012538	5 retrocopies	retro_ptro_1486, retro_ptro_3134, retro_ptro_3175, retro_ptro_3262, retro_ptro_514,
Ictidomys tridecemlineatus	ENSSTOG00000016326	1 retrocopy	retro_itri_62,
Tupaia belangeri	ENSTBEG00000011511	8 retrocopies	retro_tbel_1173, retro_tbel_1540, retro_tbel_3202, retro_tbel_3464, retro_tbel_3681, retro_tbel_3835, retro_tbel_4207, retro_tbel_4665,