RetrogeneDB ID: retro_pabe_249

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 1:65522814..65523208(+)
• Located in intron of: ENSPPYG00000000416

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: FTH1
• Ensembl ID: ENSPPYG00000003173
• Aliases: None
• Description: Ferritin heavy chain [Source:UniProtKB/Swiss-Prot;Acc:Q5R8J7]

Sequence

>retro_pabe_249
TTTGCCATGACATTTCTTCACCAATGTCATGAGGAGAGAAAATACAATGAGAAAGTGACAGAGCTGTACAACCAACAGAG
AGGCCTAATATTCCTTCGGGATATCAAGAAACCAGACCATAATGAATGGGAGGGCAGGTTGAAGACAATGGAGCATGTAT
TACACTTGGAAAAAAGCATGAATCAGTCACTACTGAAAATGCATGAACTGGCCATTGACAAAACCACACACACTGTGTGA
CTTCATTGAGATGCATTACCTGAATGAGCAGGTGAAATCTATCAAAGAACTGGGTGACCATGTTCAACTTGTCCAAGATT
GGCGGGGAGGTGGGTCTGAATCTAGCATGGCAGAGTAACTCTTTGACAAGTACACCCTGGAAGACAGTAATGAT

Alignment

ORF - retro_pabe_249 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 60.45 %
• Parental protein coverage: 71.04 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  FAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKL
          FA..FLHQ.HEER...EK...L.NQ..G.IFL.DIKKPD...WE..L..ME..LHLEK..NQSLL..H.L
Retrocopy FAMTFLHQCHEERKYNEKVTELYNQQRGLIFLRDIKKPDHNEWEGRLKTMEHVLHLEKSMNQSLLKMHEL

Parental  ATDK-NDPH-LCDFLETHYLNEQVKAIKELGDHVTNLR--KMGAPESGLAEYLFDKHTLGDSDN
          A.DK.N..H.LCDF.E.HYLNEQVK.IKELGDHV........G..ES..AE.LFDK.TL.DS..
Retrocopy AIDK<NHTH<LCDFIEMHYLNEQVKSIKELGDHVQLVQDWRGGGSESSMAE*LFDKYTLEDSND

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.28 RPM	586.52 RPM
SRP007412_cerebellum	0.12 RPM	195.78 RPM
SRP007412_heart	0.06 RPM	375.63 RPM
SRP007412_kidney	0.10 RPM	1135.61 RPM
SRP007412_liver	0.03 RPM	1030.76 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_249 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_249 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_249 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_484
Callithrix jacchus	retro_cjac_1634

---

Parental genes homology:

Parental genes homology involve 27 parental genes, and 299 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000016831	1 retrocopy	retro_amel_115,
Bos taurus	ENSBTAG00000011184	10 retrocopies	retro_btau_1151, retro_btau_121, retro_btau_1255, retro_btau_1473, retro_btau_1708, retro_btau_1745, retro_btau_256, retro_btau_595, retro_btau_673, retro_btau_959,
Canis familiaris	ENSCAFG00000015901	1 retrocopy	retro_cfam_150,
Callithrix jacchus	ENSCJAG00000019089	16 retrocopies	retro_cjac_1570, retro_cjac_1634, retro_cjac_2115, retro_cjac_2233, retro_cjac_230, retro_cjac_232, retro_cjac_2320, retro_cjac_2531, retro_cjac_278, retro_cjac_2843, retro_cjac_2857, retro_cjac_485, retro_cjac_519, retro_cjac_699, retro_cjac_767, retro_cjac_804,
Cavia porcellus	ENSCPOG00000026586	3 retrocopies	retro_cpor_1309, retro_cpor_15, retro_cpor_157,
Dasypus novemcinctus	ENSDNOG00000017128	83 retrocopies	retro_dnov_1017, retro_dnov_1074, retro_dnov_1078, retro_dnov_110, retro_dnov_1179, retro_dnov_1188, retro_dnov_1196, retro_dnov_1201, retro_dnov_1205, retro_dnov_1271, retro_dnov_1352, retro_dnov_1356, retro_dnov_1369, retro_dnov_1397, retro_dnov_1415, retro_dnov_1425, retro_dnov_1446, retro_dnov_1489, retro_dnov_1526, retro_dnov_1535, retro_dnov_1554, retro_dnov_1565, retro_dnov_162, retro_dnov_1627, retro_dnov_1640, retro_dnov_1777, retro_dnov_1787, retro_dnov_1792, retro_dnov_1827, retro_dnov_1851, retro_dnov_1865, retro_dnov_1875, retro_dnov_189, retro_dnov_197, retro_dnov_2005, retro_dnov_2065, retro_dnov_2093, retro_dnov_2097, retro_dnov_2109, retro_dnov_2124, retro_dnov_2136, retro_dnov_2154, retro_dnov_2173, retro_dnov_220, retro_dnov_2216, retro_dnov_2231, retro_dnov_2241, retro_dnov_2251, retro_dnov_2356, retro_dnov_2388, retro_dnov_2399, retro_dnov_242, retro_dnov_2443, retro_dnov_2444, retro_dnov_2454, retro_dnov_2476, retro_dnov_2483, retro_dnov_2489, retro_dnov_2511, retro_dnov_2528, retro_dnov_2554, retro_dnov_2579, retro_dnov_2607, retro_dnov_2626, retro_dnov_2646, retro_dnov_304, retro_dnov_383, retro_dnov_409, retro_dnov_422, retro_dnov_471, retro_dnov_517, retro_dnov_52, retro_dnov_55, retro_dnov_589, retro_dnov_61, retro_dnov_661, retro_dnov_675, retro_dnov_722, retro_dnov_726, retro_dnov_810, retro_dnov_864, retro_dnov_890, retro_dnov_994,
Felis catus	ENSFCAG00000007382	1 retrocopy	retro_fcat_887,
Homo sapiens	ENSG00000167996	20 retrocopies	retro_hsap_1243, retro_hsap_139, retro_hsap_1432, retro_hsap_2240, retro_hsap_2351, retro_hsap_2662, retro_hsap_2835, retro_hsap_2985, retro_hsap_2996, retro_hsap_316, retro_hsap_3208, retro_hsap_3293, retro_hsap_3589, retro_hsap_4083, retro_hsap_4232, retro_hsap_4671, retro_hsap_484, retro_hsap_81, retro_hsap_87, retro_hsap_898,
Latimeria chalumnae	ENSLACG00000017426	1 retrocopy	retro_lcha_75,
Loxodonta africana	ENSLAFG00000004824	12 retrocopies	retro_lafr_106, retro_lafr_1080, retro_lafr_1129, retro_lafr_138, retro_lafr_321, retro_lafr_433, retro_lafr_523, retro_lafr_53, retro_lafr_624, retro_lafr_717, retro_lafr_760, retro_lafr_966,
Microcebus murinus	ENSMICG00000005851	6 retrocopies	retro_mmur_1227, retro_mmur_1303, retro_mmur_1370, retro_mmur_1609, retro_mmur_392, retro_mmur_509,
Myotis lucifugus	ENSMLUG00000025726	16 retrocopies	retro_mluc_1030, retro_mluc_1142, retro_mluc_1211, retro_mluc_1354, retro_mluc_1464, retro_mluc_1769, retro_mluc_1984, retro_mluc_2002, retro_mluc_2091, retro_mluc_212, retro_mluc_2635, retro_mluc_361, retro_mluc_532, retro_mluc_556, retro_mluc_850, retro_mluc_885,
Monodelphis domestica	ENSMODG00000007582	9 retrocopies	retro_mdom_1134, retro_mdom_122, retro_mdom_1294, retro_mdom_1407, retro_mdom_1742, retro_mdom_300, retro_mdom_564, retro_mdom_643, retro_mdom_809,
Mustela putorius furo	ENSMPUG00000014030	3 retrocopies	retro_mputfur_1642, retro_mputfur_36, retro_mputfur_408,
Mus musculus	ENSMUSG00000024661	4 retrocopies	retro_mmus_2856, retro_mmus_3417, retro_mmus_3660, retro_mmus_45,
Nomascus leucogenys	ENSNLEG00000003321	29 retrocopies	retro_nleu_1036, retro_nleu_1157, retro_nleu_136, retro_nleu_1411, retro_nleu_1503, retro_nleu_1532, retro_nleu_1732, retro_nleu_1886, retro_nleu_2049, retro_nleu_2143, retro_nleu_2162, retro_nleu_2163, retro_nleu_2281, retro_nleu_2356, retro_nleu_2357, retro_nleu_2358, retro_nleu_2359, retro_nleu_2360, retro_nleu_2361, retro_nleu_2417, retro_nleu_2433, retro_nleu_2962, retro_nleu_303, retro_nleu_383, retro_nleu_72, retro_nleu_738, retro_nleu_747, retro_nleu_78, retro_nleu_936,
Oryctolagus cuniculus	ENSOCUG00000014108	4 retrocopies	retro_ocun_1172, retro_ocun_1179, retro_ocun_1598, retro_ocun_93,
Otolemur garnettii	ENSOGAG00000025354	9 retrocopies	retro_ogar_1065, retro_ogar_1198, retro_ogar_1518, retro_ogar_2010, retro_ogar_2099, retro_ogar_2349, retro_ogar_2661, retro_ogar_2747, retro_ogar_3380,
Ochotona princeps	ENSOPRG00000010734	7 retrocopies	retro_opri_1219, retro_opri_292, retro_opri_558, retro_opri_689, retro_opri_816, retro_opri_818, retro_opri_936,
Procavia capensis	ENSPCAG00000010377	13 retrocopies	retro_pcap_177, retro_pcap_217, retro_pcap_248, retro_pcap_276, retro_pcap_344, retro_pcap_348, retro_pcap_374, retro_pcap_379, retro_pcap_383, retro_pcap_395, retro_pcap_447, retro_pcap_5, retro_pcap_62,
Pongo abelii	ENSPPYG00000003173	12 retrocopies	retro_pabe_1034, retro_pabe_1186, retro_pabe_2410, retro_pabe_2483, retro_pabe_2484, retro_pabe_249 , retro_pabe_3351, retro_pabe_3406, retro_pabe_35, retro_pabe_3713, retro_pabe_47, retro_pabe_479,
Pongo abelii	ENSPPYG00000010223	11 retrocopies	retro_pabe_1362, retro_pabe_1615, retro_pabe_1690, retro_pabe_1814, retro_pabe_2514, retro_pabe_291, retro_pabe_3056, retro_pabe_3463, retro_pabe_3626, retro_pabe_3734, retro_pabe_800,
Pteropus vampyrus	ENSPVAG00000013038	3 retrocopies	retro_pvam_1006, retro_pvam_136, retro_pvam_5,
Rattus norvegicus	ENSRNOG00000022619	9 retrocopies	retro_rnor_1197, retro_rnor_1280, retro_rnor_1356, retro_rnor_1832, retro_rnor_2060, retro_rnor_2163, retro_rnor_264, retro_rnor_427, retro_rnor_71,
Sus scrofa	ENSSSCG00000014540	9 retrocopies	retro_sscr_1045, retro_sscr_168, retro_sscr_286, retro_sscr_359, retro_sscr_498, retro_sscr_581, retro_sscr_78, retro_sscr_906, retro_sscr_949,
Ictidomys tridecemlineatus	ENSSTOG00000014521	1 retrocopy	retro_itri_250,
Vicugna pacos	ENSVPAG00000003956	6 retrocopies	retro_vpac_233, retro_vpac_300, retro_vpac_370, retro_vpac_505, retro_vpac_515, retro_vpac_643,